| 黄荷凤,王曼.醋酸棉酚、GnRH－A等药物对人子宫内膜细胞雌、孕激素受体的影响[J].,1994,(6):352-353,325 |
| 醋酸棉酚、GnRH－A等药物对人子宫内膜细胞雌、孕激素受体的影响 |
| Effects of Gossypol Acetate, Danazol, Progesterone and GnRH-A on Estrogen and Progesterone Receptors of Human Endometrial Cells |
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| DOI： |
| 中文关键词: 人子宫内膜 受体 醋酸棉酚 孕酮 丹那唑 促性腺激素释放激素类似物 |
| 英文关键词:human endometrial cell receptor gossypol acetate progesterone danazol gonadotropin releasing hormone-agonist |
| 基金项目: |
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| 中文摘要: |
| 本研究观察了１０－６Ｍ醋酸棉酚、孕酮、丹那唑及促性腺激素释放激素类似物（ＧｎＲＨ－Ａ）作用离体人子宫内膜细胞后，其细胞浆雌二醇受体（Ｅ２Ｒ）、孕酮受体（ＰＲ）结合容量的变化。发现醋酸棉酚和孕酮使Ｅ２Ｒ、ＰＲ两者结合容量降低，丹那唑仅使ＰＲ结合容量降低，ＧｎＲＨ－Ａ对Ｅ２Ｒ、ＰＲ结合容量均无抑制作用。结果表明，除ＧｎＲＨ－Ａ外，其他三药通过受体调节途径影响子宫内膜细胞。 |
| 英文摘要: |
| In order to evaluate the drugs in treating endometriosis, the direct effects of gossypol acetate,danazol, progesterone, and gonadotropin releasing hormone-agonist (GnRH-A) on the isolated human endometrial cells were determined by DCC assay. The binding capacity of cytosolic estradiol receptor (E2R) and progesterone receptor (PR) in groups treated with gossypol acetate or progesterone decreased. In danazol-treated group, the binding capacity of PR decreased but not that of E2R.GnRH-A showed no significant effect on the binding capacity of E2R and PR. There was a significant linear correlation between the inhibitory rates of PR binding capacity of progesterone and danazol. The results suggested that gossypol acetate, danazol and progesterone might have peripheral effects mediated by steroid receptors,while GnRH-A work clinically through the central path way only. |
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