| 张葡萄,陈真如.复方丹参注射液对慢性肺心病患者血中脂质过氧化物及抗氧化物酶活性的影响[J].,1994,(8):474-477 |
| 复方丹参注射液对慢性肺心病患者血中脂质过氧化物及抗氧化物酶活性的影响 |
| Effect of Salvia miltiorrhiza on Lipid Peroxidation Antioxidant Enzymes Activity in Patients with Chronic Cor Pulmonale |
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| 中文关键词: 复方丹参注射液 慢性阻塞性肺疾病 氧自由基 脂质过氧化物 超氧化物歧化酶 谷胱甘肽过氧化物酶 过氧化氢酶 |
| 英文关键词:Salvia miltiorrhiza chronic obstructive pulmonary disease oxygen free radical lipid peroxidation superoxide dismutase glutathione peroxidase catalase |
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| 中文摘要: |
| 本课题研究了复方丹参液对３０例慢性肺心病患者血浆脂质过氧化物（ＬＰＯ）、红细胞超氧化物歧化酶（ＳＯＤ）、全血谷胱甘肽过氧化物酶（ＧＳＨ－ｐｘ）和过氧化氢酶（ＣＡＴ）活性的影响。结果：治疗前３０例患者的ＬＰＯ和ＳＯＤ明显高于对照组（Ｐ＜０．００１和Ｐ＜０．０５），ＧＳＨ－ｐｘ、ＣＡＴ明显低于健康对照组；治疗后丹参组４项指标均恢复到正常，而常规治疗组未能恢复正常；丹参组ＧＳＨ－ｐｘ和ＣＡＴ的增加及ＬＰＯ的降低明显大于常规组。说明丹参能明显降低慢性肺心病患者增强的脂质过氧化反应，纠正失衡的抗氧化物酶。 |
| 英文摘要: |
| This paper studied the effect of Salvia miltiorrhiza (SM) on plasma lipid peroxidation (LPO), RBC superoxide dismutase(SOD),glutathione peroxidase (GSH-Px) and catalase (CAT) activity in patients with chronic cor pulmonale. 30 patients were randomly divided into two treatment groups(routine and SM).The four parameters have been measured in 22 healthy subjects as control and patients of two treatment groups. The results showed:(1) Before treatment both treatment groups had significantly higher LPO and SOD and markedly lower GSH-Px and CAT level than that of healthy control (P<0.001) respectively. (2)After treatment in routine group the four parameters have normalized, P<0.05. (3) Routine treatment was compared with SM treatment, except SOD, the other three parameters were significantly different between two treatment groups (P<0.001). The increased levels of GSH-Px and CAT and the decreased LPO were significantly greater in SM group than routine treatment (P<0.001). The abovementioned results indicated patients with cor pulmonale in acute exacerbation their lipid peroxide reaction was enhanced, the antioxidant enzymes lost their balance. SM could attenuate markedly lipid peroxide reaction, adjust the imbalance of the three antioxidant enzymes, enhance body’s defence capability against damage of active oxygen free radical induced lipid peroxidation. |
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