欢迎访问中国中西医结合杂志！

Author Name	Affiliation
Wu Wei-kang	中山医科大学病理生理学教研室
Hou Can	中山医科大学病理生理学教研室
Luo Han-chuan	中山医科大学病理生理学教研室
卢景雾	北京医科大学天然药物与仿生药物国家重点实验室
杨正红	北京医科大学天然药物与仿生药物国家重点实验室

Hits: 1302

Download times: 967

中文摘要:

从自由基角度在小鼠垂体后叶素性心肌缺血模型上探讨四逆汤保护缺血心肌的可能机制。结果表明：四逆汤可降低缺血心肌的氧自由基（ＯＦＲ）浓度和丙二醛（ＭＤＡ）含量，增加营养血流量（ＮＢＦ）和超氧化物歧化酶（ＳＯＤ）活性。提示四逆汤保护缺血心肌是通过改善缺血心肌的灌流，减轻自由基损伤反应，加强自由基防御能力等多种机制实现的。

英文摘要:

The possible mechanisms responsible for the protective effect of Sini decoction(SND) on the ischemic myocardium were studied on the mice model of pituitrin-induced myocardial ischemia in terms of free radical.Results indicated that SND significantly decreased the concentration of oxygen free radical and the content of malondialdehyde(MDA),increased nutritional blood flow and the activity of superoxide dismutase(SOD) in ischemic myocardium.These results suggested that three mechanisms whereby SND exerted its protective effects,existedi;improving the perfusion of ischemicmyocardium,attenuating the injurious action of free radical and strengthening the free radical defense.

View Full Text View/Add Comment Download reader