| 袁健,沈锡中,竺霞霜,王毓明,郑家驹.黄连素对小肠传递时间影响的研究[J].,1994,(12):718-720 |
| 黄连素对小肠传递时间影响的研究 |
| Effect of Berberine on Transit Time of Human Small Intestine |
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| DOI： |
| 中文关键词: 黄连素 小肠传递时间 呼气氢试验 山梨醇 |
| 英文关键词:berberine small intestinal transit time breath hydrogen test sorbitol |
| 基金项目: |
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| 中文摘要: |
| 本文选用山梨醇作为试验糖，通过呼气氢试验测定小肠传递时间。３０名服１５ｇ山梨醇的健康志愿者中，２６名呼气氢含量明显升高（△Ｈ２＞５μｍｏｌ／Ｌ）；其中１８名健康志愿者服山梨醇泛影葡胺液后，１６名当泛影葡胺到达回盲部后产氢明显增高。采用呼气氢试验研究黄连素对人体小肠传递时间的影响，２０名健康志愿者基础小肠传递时间为７１．１０±２２．０４ｍｉｎ，口服１．２ｇ（０．４ｇ，每日３次）黄连素后，明显延长至９８．２５±２９．０３ｍｉｎ（Ｐ＜０．０１）。实验结果表明，黄连素能延长小肠传递时间，它的抗腹泻作用至少部分与之有关。 |
| 英文摘要: |
| Sorbitol was used as a test sugar for the determination of small intesinal transit time(SITT) by means of breath hydrogen test(BHT). After oral administration of 15g sorbital, breath hydrogen increased markedly(△ H2>5μmol/L)in 26 of 30 subjects. Following ingestion of a mixture of meglucamine diatrizoate and sorbital by 18 subjects, SITT measured by BHT correlated closely with the simultaneously determined time for the meglucamine diatrizoate in reaching ileo-cecum.The BHT was used to investigate the effect of berberine on SITT in human. SITT in 20 healthy sujects was 71.10 ± 22.04min, SITT was significantly delayed to 98.25±29.03 min after oral administration of the 1.2g of berberine (P <0.01). This result suggested that the antidiarrheal property of berberine might be mediated, at least in part, by its ability to delay the small intestinal transit. |
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