李春越,施新猷,周绍娟,张经济,任登先,桂郁富,巴善铎,孙桂华,李兴培,孙起文.胃尔康治疗慢性萎缩性胃炎的临床及实验研究[J].,1995,(1):21-24 |
胃尔康治疗慢性萎缩性胃炎的临床及实验研究 |
Clinical and Experimental Study on Gastrosia Convalescens in Treating Chronic Atrophic Gastritis |
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DOI: |
中文关键词: Gastrosia convalescens Spleen Yin Deficiency Syndrome chronic atrophic gastritis |
英文关键词:Gastrosia convalescens Spleen Yin Deficiency Syndrome chronic atrophic gastritis |
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中文摘要: |
本研究临床观察了胃尔康片对慢性萎缩性胃炎(CAG)脾胃阴虚证的疗效。采用单盲法,对照药为维酶素。两组服药前后作纤维胃镜及病理活检。结果:治疗组323例中临床治愈118例(36.53%),显效135例(41.79%),有效61例(18.89%),无效9例(2.79%);总有效率97.21%。对照组105例中显效8例(7.62%),有效35例(33.33%),无效62例(59.05%);总有效率40.95%。两组比较差异有显著性意义(x2=166.6,P<0.01)。病理检查显示肠上皮化生及不典型增生消失率治疗组均优于对照组(p<0.01)。实验研究采用Wistar大鼠作CAG模型及胃尔康的长期毒性试验,应用狗作胃尔康对胃肠电活动影响的试验。结果:胃尔康长期毒性试验表明,高剂量(10g/kg)组有轻度兴奋反应,中(5g/kg)、低(1g/kg)剂量组无毒副反应。动物CAG模型试验表明,胃尔康有显著的消炎、强壮、健脾作用外,还有促进萎缩腺体再生和修复之功效。对狗胃肠电活动影响,主要起兴奋作用,优于吗丁啉(P<0.05)。 |
英文摘要: |
Gastrosia convalescens(GC)is a new drug for treating the Spleen-Yin Deficiency syndrome of chronic atrophic gastritis(CAG).Animal experiment has shown that GC has the function of promoting the regeneration of atrophic glands,and that of anti-inflammation, reinforcing,strengthening the stomach etc.It has the effect on the intestinal electric activity in dogs,mainly exciting in action,which was superior than that of domperidoni(P<0.05).The result of clinical study has demonstrsted that the marked effective rate of GC was 78.32%,CAG reversed into chronic superficial gastritis(CSG) in 30.0% of patients(60/200 cases),CAG into chronic superficial atrophic gastritis(CSAC)in 39.0%(78/200 cases).and CSAG into CSG in 39.02%(48/123 cases).The disappearance rate of metaplasia of intestinal epithelium and atypical hyperplasia were 39.1% and 38.14% respectively.There was a very significant difference in comparing with control group(P<0.01). |
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