陈立新,廖家桢,郭维琴,于维杰,秦腊梅.黄芪对急性心肌梗塞患者心功能和氧自由基的影响及黄芪强心机制探讨[J].,1995,(3):141-143 |
黄芪对急性心肌梗塞患者心功能和氧自由基的影响及黄芪强心机制探讨 |
Effects of Astragalus membranaceus on Left Ventricular Function and Oxygen Free Radical in Acute Myocardial Infarction Patients and Mechanism of Its Cardiotonic Action |
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DOI: |
中文关键词: 黄芪 急性心肌梗塞 射血前期/左室射血时间 超氧化物歧化酶 过氧化脂质 |
英文关键词:Astragalus membranaceus acute myocardial infarction pre-ejection period/left ventricular ejection time superoxide dismutase lipid peroxidation |
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中文摘要: |
对初次发病且发病后36h内收住冠心病监护室的43例急性心肌梗塞(AMI)患者,采用黄芪口服液治疗,进行了4周心功能的动态观察。研究表明,黄芪(60g/d)可使AMI患者药后射血前期/左室射血时间(PEP/LVET)比值显著下降,优于基础治疗组;同时提高AMI患者红细胞超氧化物歧化酶(SOD)活性,降低血浆过氧化脂质(LPO)含量,作用均优于基础治疗组;并证明了PEP/LVET比值与SOD活性、LPO含量的相关性。研究表明,黄芪抗氧自由基的作用可能是其强心作用机制之一。 |
英文摘要: |
Dynamic observations for 4 weeks were made on left ventricular function and oxygen free radical (OFR) in 43 patients first suffering from acute myocardial infarction and hospitalized in Coronary Care Unit with an attack less than 36 hours. The results showed that the Astragalus membranaceus (AM) could strengthen the left ventricular function and had an effect of anti-OFR.After administration of AM, the ratio of pre-ejection period/left ventricular ejection time (PEP/LVET) was decreased, the superoxide dismutase (SOD) activity of red blood cell was increased, and the lipid peroxidation (LPO) content of plasma was reduced. There was a significant difference between the AM group and the control group in the parameters above-mentioned.The study demonstrated that the PEP/LVET ratio was closely correlated with the SOD and LPO. It suggested that the anti-OFR effect of AM was one of the mechanisms of its cardiotonic action. |
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