| 魏强华,郑秀春,石蕴玉,沈博生,傅亚萌,孙瑾,张镜人.复方四参饮对病毒性心肌炎患者细胞免疫功能的影响[J].,1995,(3):144-146 |
| 复方四参饮对病毒性心肌炎患者细胞免疫功能的影响 |
| Effect of Fu-Fang Si-Shen Yin on Cellular Immunity in Patients with Viral Myocarditis |
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| DOI： |
| 中文关键词: 复方四参饮 病毒性心肌炎 自然杀伤细胞 T淋巴细胞亚群 |
| 英文关键词:Fu-Fang Si-Shen Yin viral myocarditis natural killer cell activity T lymphocyte subsets |
| 基金项目: |
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| 中文摘要: |
| 为了研究复方四参饮对病毒性心肌炎患者细胞免疫功能的影响，测定了６０例患者的自然杀伤细胞（ＮＫ细胞）活性和２０例患者的Ｔ淋巴细胞亚群。结果除了ＯＫＴ８外都显著低于正常值（Ｐ＜０．０１）。经复方四参饮治疗后，除ＯＫＴ８外皆有显著升高（Ｐ＜０．０５）。中医辩证分型表明，ＮＫ细胞功能下降以气阴两虚组为明显，而Ｔ细胞亚群的改变以气虚组为显著。ＮＫ细胞活性与ＯＫＴ４／ＯＫＴ８值呈负相关（Ｐ＜０．０５）。此外，早期ＮＫ细胞功能状况与疾病预后关系密切。 |
| 英文摘要: |
| In order to study the effect of the Fu-Fang Si-Shen Yin （FFSSY） on cellular immunity, the natural killer （NK） cell activity of 60 patients with viral myocarditis, while the lymphocyte subsets consisted of OKT3, OKT4, OKT8,OKT4/OKT8 of other 20 patients were determined.The pretreatmental results were 25.25±10.46%, 59. 11±8.72%, 30.72±6.94%, 29.72±5.35% and 1. 04±0 . 24 respectively, which were significantly lower than that of the normal value （P<0. 01）except OKT8. However,after the treatment with FFSSY, NK cell activity and OKT3, OKT4, OKT4/OKT8 were elevated to 30. 96±10. 13% （P< 0. 05） , 62. 33± 7. 78% （P< 0. 05） , 33. 67±5. 50% （P<0. 05） and 1. 14±0 . 20 （P< 0. 01） respectively. The Syndrome Differentiation of TCM indicated that NK cell activity decreased obviously in the Qi-Yin-Deficiency group, while T lymphocyte subsets changed significantly in the Qi-Deficiency group. There existed negative correlation between NK cell activity and OKT4/OKT8 （r=-0 . 60, P<0 . 05）. The patients with high NK cell activity in the early stage could have a favourable prognosis, while unfavourable with low NK cell activity. |
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