| 王淑媛,马鸿,郝彦威.蚂蚁合剂对矽肺防治效果的实验病理学研究[J].,1995,(4):228-230 |
| 蚂蚁合剂对矽肺防治效果的实验病理学研究 |
| Pathologic Studies on Preventive and Therapeutic Effects of the Formic Mixture on Experimental Silicosis |
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| DOI： |
| 中文关键词: 蚂蚁合剂 矽肺防治 实验性矽肺 |
| 英文关键词:formic mixture prevention and therapy of silicosis experimental silicosis |
| 基金项目: |
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| 中文摘要: |
| 为了观察蚂蚁合剂对矽肺的防治效果，将９６只Ｗｉｓｔａｒ种大鼠随机分为３组：预防组、治疗组和对照组。所有动物均以石英尘气管注入染尘，于注入染尘后１、３、６和１２个月，将各组动物分批处死，取肺进行病理学研究。结果表明，矽肺纤维化进展程度各组间有明显不同，以对照组最重，治疗组次之，预防组最轻。不论肺组织的纤维化级或纤维化量，预防组与对照组间均有显著性差异（Ｐ＜０．０５，Ｐ＜０．０１）。治疗组与对照组间纤维化级的比较，亦有显著性差异（Ｐ＜０．０５），但预防组与治疗组间无显著性差异。本结果证明，蚂蚁合剂能明显抑制矽肺纤维化，为其临床应用提供了依据。 |
| 英文摘要: |
| In order to investigate the preventive and therapeutic effects of formic mixture on experimental silicosis,96 Wistar rats were divided randomly into three groups,lst group was taken as preventive administration(Two days before exposure to dust),2 nd group-therapeutic administration(one month after exposure to dust) and 3rd control group-model of silicosis.All above-mentioned animals were instilled intratracheally with standard quartz dust.At lst,3 rd,6 th and 12 th month after instillation of dust,rats from each group were sacrificed and pathohistologic studies were performed on their lung tissue.The results showed that the progressive degree of silicotic fibrosis in various groups were greatly different,i.e.3 rd group was severest,2 nd group medium,and lst group was mildest.Either the differences of grade or quantity of fibrosis in lung tissue was significant between lst and 3 rd group,P<0.01.The difference of the grade of fibrosis between 2 nd and 3 rd group was also significant,P<0.05, but that between lst and 2 nd group was insignificant.The results demonstrated that administration of formic mixture, in particular,preventive administration,could inhibit greatly the process of silicotic fibrosis,and provided a basis for clinical application of this drug. |
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