| 王跃红,徐凯建,江伟世,吕福贞,胡孟英,何晓莲,洪凤阳,哲增科,高峰,张晶伟.双黄连气雾剂治疗急性呼吸道感染临床观察[J].,1995,(6):347-350 |
| 双黄连气雾剂治疗急性呼吸道感染临床观察 |
| Experimental and Clinical Study of Shuanghuanglian Aerosol in Treating Acute Respiratory Tract Infection |
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| DOI： |
| 中文关键词: 双黄连气雾剂 急性呼吸道感染 抑制病毒 抑菌谱 |
| 英文关键词:Shuanghuanglian aerosol acute respiratory infection virus inhibition antibiogram |
| 基金项目:黑龙江省八五攻关课题 |
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| 中文摘要: |
| 本研究应用双黄连气雾剂治疗急性呼吸道感染（ＡＲＩ）２０２例。通过对２６种病毒、２３种细菌的人体和家兔体内外的抑病毒、抑菌试验证明：该药对呼吸道合胞病毒、副流感病毒Ⅰ～Ⅳ型、金黄色葡萄球菌等细菌均有直接抑制作用，抑菌力与药物浓度呈正相关。实验研究证明：该中药具有增强ＮＫ细胞活性，促进α－干扰素生成的作用。临床上对不同剂型的双黄连制剂进行了比较观察，结果表明：治疗早期ＡＲＩ，气雾剂治疗组在控制临床症状、体征方面疗效优于注射液和口服液（Ｐ＜０．０５），总有效率为９６％。 |
| 英文摘要: |
| Two hundrde and two cases of acute respiratory tract infection(ARI)were treated with Shuanghuanglian(SHL)aerosol.In these cases,the majority of cases were virus infection and 64% of them was caused by the respiratory syncytial virus(RSV).The virostatic and bacteriostatic test were done in vitro by the cell culture method and it was shown that SHL could inhibit the RSV,para-influenza Ⅰ～Ⅳand 23 kinds of pathogenic bacteria such as Staphylococcus aureus etc.The bacteriostatic effect was positively correlated to the SHL concentration.Experimental study showed that SHL could enhance the NK cell activity,promote the production of α-interferon and raise the rate of lymphocyte transformation.The controlled observation on SHL preparation with various dosage-forms revealed that the SHL aerosol in treating early ARI showed better results than that of injections and oral liquor symptomatologically(p<0.01).The effective rate was 96%. |
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