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Author Name	Affiliation
Wu Chao-dong	武汉同济医科大学中西医结合研究所
Li Ming-zhen	武汉同济医科大学中西医结合研究所
Zhang Yan-ping	武汉同济医科大学中西医结合研究所
林宝英	武汉同济医科大学中西医结合研究所
罗明	第二军医大学长梅医院中医科
徐丽君	武汉同济医科大学中西医结合研究所

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中文摘要:

通过Ｅｌｉｓａ检测内毒素ＤＩＣ家兔血浆肿瘤坏死因子α（ＴＮＦ－α）、白细胞介素６（ＩＬ－６）水平变化，并观察中药热毒清注射液对ＴＮＦ－α、ＩＬ－６水平的影响。结果发现，模型组血浆ＴＮＦ－α、ＩＬ－６水平显著升高，其升高水平和组织、器官的损害程度相一致。运用热毒清作为防治处理后，ＴＮＦ－α、ＩＬ－６水平显著降低，组织、器官的损害也相应较轻。以上结果提示ＴＮＦ－α、ＩＬ－６参与ＤＩＣ发病机制，中药热毒清通过降低ＴＮＦ－α、ＩＬ－６水平可能对ＤＩＣ具有防治作用。

英文摘要:

Plasma TNF-αand IL-6 levels of endotoxin-induced DIC in rabbits were measured by ELISA methods.Simultaneously,the effects of Reduqing(RDQ)on TNF-αand IL-6 were also studied.The results showed that TNF-αand IL-6 levels increased markedly in model group,which were confirmed with obvious damage of tissue or organ.Co-administration of RDQ could reduce plasma TNF-αand IL-6 levels,together with mild tissue or organ damage.These results indicated TNF αand IL-6 might be involved in pathogenesis of endotoxin-induced DIC,RDQ might be used in preventing or treating DIC through mechanism of reducing TNF-αand IL-6 levels.

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