| 徐西,王硕仁,林谦.党参口服液治疗25例冠心病血瘀证患者临床及实验研究[J].,1995,(7):398-400 |
| 党参口服液治疗25例冠心病血瘀证患者临床及实验研究 |
| Clinical and Experimental Study on Codonopsis Pilosula Oral Liquor in Treating Coronary Heart Disease with Blood Stasis |
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| 中文关键词: 冠心病 血瘀证 组织型纤溶酶原激活物 纤溶酶原激活物抑制物 党参口服液 |
| 英文关键词:coronary heart disease blood stasis tissue-type plasminogen activator plasminogen activator inhibitor Codonopsis pilosula oral liquor |
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| 中文摘要: |
| 以２１名健康人及５２例冠心病血瘀证患者为对象，用发色底物法测定其血浆组织型纤溶酶原激活物（ｔ－ＰＡ）及其抑制物（ＰＡＩ）活性变化。结果表明，冠心病血瘀证患者血浆ｔ－ＰＡ活性明显降低，与健康人比较，有显著性意义（Ｐ＜０．０１）。又经党参口服液对２５例冠心病气虚血瘀证患者血浆ｔ－ＰＡ及ＰＡＩ活性以及血小板聚集功能的治疗观察，发现治疗后，血小板聚集功能明显降低，而对ｔ－ＰＡ及ＰＡＩ活性无明显影响。提示党参口服液的活血作用主要是通过抑制血小板功能影响凝血过程，而非提高血浆纤溶活性而实现的。 |
| 英文摘要: |
| The effects of Codonopsis pilosula oral liquor(CPOL) on tissue-type plasminogen activator(t PA) and plasminogen activator inhibitor(PAI) in the plasma of 25 patients of coronary heart disease with blood stasis were studied.It has been shown that those patients had a significant decrease in t-PA activity(P<0.01) compared to healthy subjects.After 4 weeks of CPOL therapy,platelet aggregation significantly decreased(p<0.05).there was no significant difference in t-PA and PAI.From the results shown above,it suggested that one of the effects of CPOL in influencing blood coagulation was its inhibition on platelet aggregation,but not through the elevating of fibrinolytic activity. |
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