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Author Name	Affiliation
She Wan-dong	南京大学医学院附属鼓楼医院耳鼻喉科
Chen Zhao-he	南京大学医学院附属鼓楼医院耳鼻喉科

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中文摘要:

通过检测豚鼠耳蜗组织超氧化物歧化酶（ＳＯＤ）、丙二醛（ＭＤＡ），结合耳蜗电图和形态学观察，评价川芎嗪（ＴＭＰ）对卡那霉素（ＫＭ）耳中毒的防治作用。结果显示，ＫＭ能显著增加ＳＯＤ活力和ＭＤＡ含量，使听力下降，ＴＭＰ能显著降低ＳＯＤ活力和ＭＤＡ含量，听力得以改善。推测脂质过氧化反应参与了ＫＭ耳中毒过程，ＴＭＰ通过抗氧化作用减轻ＫＭ耳毒性。

英文摘要:

By measuring cochlear superoxide dismutase (SOD) activity, malondialdehyde (MDA) and electrocochleogram (ECoG) in guinea pigs, the antioxidation of Ligustrazine on Kanamycin (KM) was studied. The results showed that SOD activity, MDA content and threshold value of ECoG were significantly increased after KM was adininistered, while it markedly reduced after Ligustrazine was given. It was considered that lipid hyperoxidative reaction was correlated with KM ototoxicity,Ligustrazine could prevent and treat KM ototoxicity by antioxidation.

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