| 鄢顺琴,凤良元,苏英豪,陈向涛,许家林.胃痛灵保护胃粘膜作用及对胃溃疡愈合质量的影响[J].,1995,(10):612-614 |
| 胃痛灵保护胃粘膜作用及对胃溃疡愈合质量的影响 |
| Protective Effect of "Wei Tong Ling" on Gastric Mucosa and Influence on Quality of Gastric Ulcer Healing |
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| DOI： |
| 中文关键词: 胃痛灵 胃溃疡 胃粘膜 再生粘膜 |
| 英文关键词:Wei Tong Ling gastric ulcer gastric mucosa regenerated mucosa |
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| 中文摘要: |
| 采用无水乙醇、０．６ＮＨＣｌ、０．６ＮＮａＯＨ等诱发大鼠急性胃溃疡，并用冰醋酸引发慢性溃疡模型，观察中药胃痛灵对胃粘膜的保护作用。用粘液组织化学染色、ＡｇＮＯＲ染色和免疫组化染色对大鼠愈合性胃溃疡再生粘膜进行定量观察，用胃痛灵治疗后和自然愈合的溃疡粘膜作比较。结果显示愈合性胃溃疡再生粘膜可能是胃溃疡复发的形态学基础，并可能与癌变有关；胃痛灵不仅能促进溃疡愈合，而且能提高胃溃疡的愈合质量，有助于防止胃溃疡的复发与癌变。 |
| 英文摘要: |
| The acute gastric ulcer rat models were induced by dehydrated alcohol, 0.6 N hydrochloric acid and 0. 6 N sodium hydroxide, and the chronic gastric ulcer rat models were established by means of acetic acid, the protective effect of Chinese medicine "Wei Tong Ling"(WTL) on gastric mucous membrane was studied. Using histochemical mucin stain, AgNOR stain and immunohistochemical technique the regenerated mucosa of healed gastric ulcer induced by acetic acid in rats was observed quantitatively. They were compared with that of WTL. The results showed that the regenerated mucosa of healed gastric ulcer might be the morphological basis for the recurrence of gastric ulcer and be associated with canceration. WTL could not only accelerate the healing of ulcer but also raise the quality of gastric ulcerous healing which was beneficial for the prevention of ulcer recurrence and canceration. The protective effect of WTL on gastric mucosa was comfirmed by various assays. |
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