欢迎访问中国中西医结合杂志！

Author Name	Affiliation
Tang Li-long	北京医科大学附属第一医院心内科
Wang Li-hui	北京医科大学附属第一医院心内科
Zhang Jun-hua	北京医科大学附属第一医院心内科
朱国英	北京医科大学附属第一医院心内科
张小荣	甘肃省中医院风湿科

Hits: 1698

Download times: 1442

中文摘要:

为了观察川芎嗪对冠状动脉成形术（ＰＴＣＡ）后再狭窄的治疗作用及其活血化瘀的可能机制，我们用４０μｇ川芎嗪来处理培养血管平滑肌细胞（ＶＳＭＣｓ），应用Ｎｏｒｔｈｅｒｎ杂交的方法观察了川芎嗪对培养ＶＳＭＣｓ前胶原α１（Ⅰ）、α１（Ⅲ）基因转录的影响，发现川芎嗪能明显抑制α１（Ⅰ）、α１（Ⅲ）基因的转录。

英文摘要:

For the purpose of studying the mechanism of tetramethylpyrazine(TMP) to prevent the restenosis after percutaneous transluminal coronary angioplasty(PTCA) and promote blood circulation to remove stasis.40μg of TMP was used to treat cultured vascular smooth muscle cells (VSMs).The total RNA was extracted from treated VSMC.The RNA Northern blot hybridization with procollagen genesαi-Ⅰandα1-Ⅲ probes was used to investigate its change in mRNA level.The results indicated that TMP could inhibit significantly the transcription of procollagen genesα1-Ⅰ andα1-Ⅲ.

View Full Text View/Add Comment Download reader