| 尹光耀,何雪芬,尹玉芬,张武宁,杜永清,陈志范.脾虚证患者胃粘膜线粒体超微结构、微量元素及相关因素的研究[J].,1995,(12):719-723 |
| 脾虚证患者胃粘膜线粒体超微结构、微量元素及相关因素的研究 |
| Study on Mitochondrial Ultrastructure,Trace Elements and Correlative Factors of Gastric Mucosa in Patients with Spleen Deficiency Syndrome |
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| DOI： |
| 中文关键词: 脾虚证胃病 线粒体退变 线粒体微量元素 环磷酸腺苷 超氧化物歧化酶 |
| 英文关键词:gastric disease with Spleen deficiency syndrome degeneration of mitochondria mitochondrial trace elements cyclic adenosine monophosohate superoxide dismutase |
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| 中文摘要: |
| 脾虚证胃病患者８８例经透射电镜、能量色散Ｘ射线分析仪、组织化学染色和放射免疫等检测，发现胃粘膜ｃＡＭＰ、ＳＯＤ含量、线粒体及其嵴的数量、线粒体室腔内径比值和Ｚｎ、Ｃｕ含量减少，其趋势是随健康对照组、脾气虚证组、脾虚气滞证组；慢性浅表性胃炎组、慢性萎缩性胃炎组、胃癌组；完全性、不完全性小肠型肠化生组、完全性、不完全性结肠型肠化生组的顺序递减，Ｐ＜０．０５～０．００１。线粒体退变率、Ｃｕ／Ｚｎ比值、胃粘膜肠化生率、不完全性结肠型肠化生率和血清ＬＰＯ则随以上顺序递增，Ｐ＜０．０５～０．００１。提示线粒体退变及其相关因素量变的综合作用，是引起脾虚证、胃粘膜肠化生和癌变的病理生理学基础。临床上应高度重视脾虚气滞证胃病的癌变倾向。 |
| 英文摘要: |
| Eighty-eight gastropathic patients with Spleen deficiency syndrome by using transmission electron microscope(TEM),X-ray energy disperse analysis system(EDAX),histochemical staining and radioimmuno methods were examined.The authors found that the gastric mucosa cAMP,SOD Level,the quantity of mitochondria and its crista,the ratio of diameter between ventricle and cavity of mitochondria and the content of Zn,Cu of mitochondria were reduced in the trend of healthy control group,Spleen Qi deficiency group,Spleen deficiency with Qi stagnation group, chronic superficial gastritis group,chronic atrophic gastritis group,gastric cancer group:complete small intestinal metaplasia group,incomplete small intestinal metaplasia group,complete colonic intestinal metaplasia group,incomplete colonic intestinal metaplasia group(P<0.05～0.001).While the degeneration rate of mitochondria,the Cu/Zn ratio of mitochondria,the metaplasia rate of gastric,the rate of incomplete colonic intestinal metaplasia and the content of serum LPO were increased in the above turn.It is suggested that the comprehensive effect of the degeneration of mitochondria and the quantitative changes of its correlative factors is the physiopathologic base for inducing Spleen deficiency disease,gastric mucosa metaplasia and canceration.Much attention must be paid in clinic to the cancerization trend of gastric disease with Spleen deficiency syndrome. |
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