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Author Name	Affiliation
陈群	广东医学院微生物学教研室
陈南菊	广东医学院微生物学教研室
王胜春	广东医学院微生物学教研室

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中文摘要:

本研究以中药黄连的提取物为质粒消除剂，用携带Ｒ质粒的多重耐药性大肠杆菌Ｅ．１０２株为靶细菌，进行了体外Ｒ质粒消除作用的实验研究。同时观察了黄连作用不同时间，对大肠杆菌Ｒ质粒消除作用的影响。实验结果表明：黄连具有消除Ｒ质粒的作用。经黄连作用２４ｈ，消除率为２．４２％，延长作用时间至４８ｈ，其消除率提高为２２．５７％。细菌丢失的耐药性可以表现为单一或两种耐药性的丧失。

英文摘要:

The R plasmid curing experiment was performed in vitro with E.coli strain E. 102 bearing R plasmid as target bacteria and Coptis chinensis as elimination agent. The influence of different time on R plasmid elimination was also observed. Results showed that when the acting time was 24 hours, the cure rate of R plasmid was 2 . 42% and when the acting time increased to 48 hours, the cure rate elevated to 22 . 57%. The Missing patterns of R plasmid might be occurred in disappearence of either multiple or single resistance.

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