| 冯卫红,侯家玉.沙参麦冬汤对动物在体胃运动的影响[J].,1996,(3):164-166 |
| 沙参麦冬汤对动物在体胃运动的影响 |
| Effect of Shashen Maidong Decoction on Gastric Motility in vivo |
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| DOI： |
| 中文关键词: 沙参麦冬汤 胃排空 胃内压 胃底纵行肌 胃窦环行肌 消炎痛 利血平 |
| 英文关键词:Shashen Maidong Decoction gastric emptying intragastric pressure fundic longitudinal muscle antral circular muscle indomethacin reserpine |
| 基金项目:国家自然科学基金 |
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| 中文摘要: |
| 本实验观察了沙参麦冬汤水煎液对动物胃运动功能的影响。结果表明，沙参麦冬汤（２３ｇ／ｋｇ）１次给药及９ｇ·ｋｇ－１·ｄ－１及２３ｇ·ｋｇ－１·ｄ－１连续５天灌服均能显著抑制小鼠胃酚红排空率（Ｐ＜０．０５），９ｇ／ｋｇ、２３ｇ／ｋｇ１次给药能对抗新斯的明引起的小鼠胃排空加快（Ｐ＜０．０５，Ｐ＜０．０１）；胃浆膜埋植应变片记录清醒大鼠胃运动发现，该方７ｇ／ｋｇ灌胃能抑制大鼠胃底纵行肌收缩的频率和幅度，对胃窦环行肌作用不明显；胃内埋植水囊法观察到，沙参麦冬汤（３．５ｇ／ｋｇ，７ｇ／ｋｇ）十二指肠给药能使麻醉大鼠胃运动的频率减慢，幅度减弱，其中７ｇ／ｋｇ该方对皮下注射消炎痛（４０ｍｇ／ｋｇ）引起的大鼠胃运动亢进有显著抑制作用，但对肌肉注射利血平（０．４ｍｇ·ｋｇ－１·ｄ－１×４ｄ）引起的大鼠胃运动加强作用不明显。 |
| 英文摘要: |
| Effect of Shashen Maidong Decoction(SSMDD) on the’gastric motility of mice and rats was observed in vivo. Results showed that the gastric phenol red excretion rate of mice could be reduced markedly by SSMDD given in various dosages(23g·kg-1·d-1, 9g·kg-1·d-1 or 23g·kg-1·d-1 for 5 days successively), P<0.05. By administration of 9g·kg-1·d-1 or 23g·kg-1·d-1 could antagonize the acceleration of gastric emptying induced by neostigmine in mice(P<0.05, P<0.01).7g/kg of SSMDD by gastrogavage could iuhibit the frequency and amplitude of contraction of fundic longitudinal muscle using strain gauge transducer in rats, but the effect was not obvious on that of antral circular muscle. By water-ballon method, it was observed that SSMDD 3.5 g/kg or 7g/kg intraduodenal perfusion could slow down the frequency and decrease the amplitude of gastric peristalsis, 7g/kg could inhibit significantly the gastric hypermotility induced by subcutaneous injection of indomethacin(40mg/kg), but had no obvious effect on the gastric hapermotility induced by intramuscular injection of reserpine (0.4mg·kg-1·d-10×4d). |
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