| 蔡沛源,徐宝甜,沈百余.合欢汤治疗冠心病临床研究[J].,1996,(4):204-206 |
| 合欢汤治疗冠心病临床研究 |
| A Clinical Study of Hehuantang in Treating Coronary Heart Disease |
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| DOI： |
| 中文关键词: 合欢汤 应激 心绞痛 抗氧化酶 氧自由基 |
| 英文关键词:Hehuantang stress angina pectoris antioxidase oxygen radicals |
| 基金项目: |
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| 中文摘要: |
| 将５９例冠心病患者分为中药合欢汤组（３７例）和心痛定对照组（２２例）进行自身治疗前后对照和组间比较。结果：合欢汤组缓解心绞痛显效率和总有效率分别为７５．６８％与９１．８９％；治疗后血清超氧化物歧化酶（ＳＯＤ）、全血谷胱甘肽过氧化物酶（ＧＳＨ－Ｐｘ）活性显著高于治疗前（Ｐ＜０．０１）；且ＳＯＤ活性、ＧＳＨ－ＰＸ／ＬＰＯ比值高于对照组（Ｐ＜０．０１与Ｐ＜０．０５）、ＬＰＯ含量低于对照组（Ｐ＜０．０５）。提示合欢汤具有抗心绞痛、升高抗氧化酶活性、降低脂质过氧化作用。 |
| 英文摘要: |
| Fifty-nine cases with angina pectoris(AP) in coronary heart disease were divided randomly into two groups,37 cases of Hehuantang group(HT) treated with Hehuantang,22 cases of patient treated with nifedipine tablet was taken as control group(CG).The results:(1) the marked effective and total effective rate in allevating AP was 75.68% and 91.89% in HT respectively;(2) activities of serum SOD and whole blood GSH-Px in HT significantly elevated than that pretreatmentally(P<0.01);(3) comparing with CG,SOD activity and GSH-Px/LPO ratio increased(P<0.01 and P<0.05),whereas plasma LPO content lowered(P<0.05).It suggested that HT having effects of relieve AP and enhance antioxidative activity and attenuate lipid peroxide reaction.The mechanism might be correlated to inhibit the calcium overload and reduce LPO production in cardiac cell as well as improve blood supply to myocardial ischemia. |
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