| 刘克洲,徐陈槐,章明太,陈智,顾亚仙,蔡培仁,何南祥,金建华,徐辉,华炯钢,陈明华,陈宝珠.复方黄芪治疗慢性乙型肝炎的临床及实验研究[J].,1996,(7):394-397 |
| 复方黄芪治疗慢性乙型肝炎的临床及实验研究 |
| Clinical and Experimental Studies on Effects of Chronic Hepatitis B Treated with Astragali Composita |
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| DOI： |
| 中文关键词: 复方黄芪 慢性乙型肝炎 鸭乙型肝炎模型 |
| 英文关键词:Astragali Composita chronic hepatitis B duck hepatitis B model |
| 基金项目:浙江省中医管理局、浙江省教委资助 |
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| 中文摘要: |
| 用复方黄芪治疗慢性迁延性肝炎８７例和慢性活动性肝炎２９例，临床显效率分别为６９．０％和５５．２％，总有效率分别为９０．８％和８９．７％；血清ＨＢｅＡｇ和ＨＢＶ－ＤＮＡ阴转率分别为２７．７％和２８．０％，均显著高于对照组（Ｐ＜０．０５～０．０１）。治疗鸭乙型肝炎模型８只，血清ＤＨＢＶ－ＤＮＡ阴转３只，ＤＨＢＶ－ＤＮＡ平均水平治后比治前明显下降（Ｐ＜０．０５）；鸭肝组织呈轻度炎症改变者３只，病变比对照组轻，原位杂交ＤＨＢＶ－ＤＮＡ定位２只鸭阴性。结果显示，复方黄芪具有较好保肝和一定的抑制ＨＢＶ复制作用。 |
| 英文摘要: |
| Eighty-seven cases of chronic persistent hepatitis(CPH) and 29 cases of chronic active hepatitis(CAH) were treated with Astragali Composita(AC),the clinical markedly effective rates were 69.0% and 55.2%,the total effective rates were 90.8% and 89.7% respectively,the sero-negative conversion rates of HBeAg and HBV-DNA were 27.7% and 28.0% respectively,they were higher than that of control group(P<0.05￣0.01).Eight ducks infected duck hepatitis B virus were treated with AC,sero-negative conversion of DHBV-DNA was seen in 3 ducks,DHBV-DNA levels of duck sera were lower after treatment than that before treatment(P<0.05);mild inflammatory changes in liver tissues were seen in 3 ducks,its pathologic changes were milder than that of control groups;DHBV-DNA in liver tissues of 2 ducks was negative in situhybridization.The results indicated that AC had obvious effects of protecting liver tissues and some effects of inhibiting sera HBV and HBV replication. |
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