| 陈敏光,王其豪,林玮,林玉冰,陈孔利,刘飞,林芩,林华阳,蔡宏达,林求诚.高乌甲素复合液硬膜外腔注射对术后镇痛的临床研究[J].,1996,(9):525-528 |
| 高乌甲素复合液硬膜外腔注射对术后镇痛的临床研究 |
| Clnical Study in Epidural Injection with Lappaconitine Compound for Post-Operative Analgesia |
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| DOI： |
| 中文关键词: 高乌甲素复合液 布比卡因 吗啡 硬膜外腔 术后镇痛 |
| 英文关键词:Lappaconitine Compound bupivacaine morphine epidural injection postoperative analgesia |
| 基金项目:福建省教委科技三项费用资助课题 |
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| 中文摘要: |
| 本研究观察高乌甲素复合液硬膜外腔注射对术后镇痛的效能和副作用。１２０例患者随机分为４组，Ⅰ组为观察组，用高乌甲素１２ｍｇ和布比卡因２２．５ｍｇ的复合液（ＬＢ液）；Ⅱ、Ⅲ、Ⅳ３组为对照组，分别单用高乌甲素１２ｍｇ、布比卡因２２．５ｍｇ、吗啡２ｍｇ，于术后切口复痛时，以单盲法将药液注入硬膜外腔。结果：镇痛起效时间是Ⅰ组、Ⅲ组快于Ⅱ组、Ⅳ组，镇痛效力强度是Ⅳ组＞Ⅰ组＞Ⅲ组＞Ⅱ组，以上两项的Ⅰ、Ⅱ组比较均有显著性差异（Ｐ＜０．０１，Ｐ＜０．０５）。而单次镇痛作用持续时间的长短顺序是Ⅳ组＞Ⅰ组＞Ⅱ组＞Ⅲ组，其中Ⅰ、Ⅳ组比较有显著性差异（Ｐ＜０．０１）。表明ＬＢ液的硬膜外术后镇痛效能较单用高乌甲素可更快、更好地达到临床术后镇痛要求，且不良反应少，比吗啡安全。 |
| 英文摘要: |
| In this study, the effect and side-effect of epidural injection with lappaconitine compound for post-operative analgesia was observed. One hundred and twenty patients were randomly divided into 4 groups. Lappaconitine compound (LB) consisted of 12mg of lappaconitine and 22.5mg of bupivacaine, was given to group A (the group of observation), and lappaconitine 12mg, bupivacaine 22.5mg and morphine 2mg to group B, C and D respectively for control. All were given by epidural injection with single blind method during post-operative pain of incision operation. Result showed that the initiating of analgesia was quicker in group A and C than that in group B and D, and the efficacy was group D>A>C>B. There was significant difference between group A and B in the above two parameters, P<0.01 and P<0.05. The analgisia maintenence time of single injection was D>A>B>C, that of group D was significantly longer than that of group A (P<0.01). Itindicated that the epidural injection with LB was more rapid and potent than that with lappaconitine alone in post-operative analgesia, and the former had no side-effect, it was safer than morphine. |
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