| 潘明政,郭赛珊,梁晓春,陈祥银,西品香,王香定,田国庆,张克俭,申涛.中药仙贞片对气阴两虚肾虚血瘀型糖尿病患者红细胞膜Na~+-K~+-ATP酶等的影响[J].,1997,(1):13-16 |
| 中药仙贞片对气阴两虚肾虚血瘀型糖尿病患者红细胞膜Na~+-K~+-ATP酶等的影响 |
| Effect of Xianzhen Tablet on Na+-K+-ATPase, Ca2+-Mg2+-ATPase, of Red Blood Cell Membrane in Patients with Non-Insulin Dependent Diabetes Mellitus |
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| DOI： |
| 中文关键词: 糖尿病 非胰岛素依赖型 红细胞膜 Na~＋－K~＋－ATP酶 Ca2＋－Mg2＋－ATP酶 全血粘度 |
| 英文关键词:diabetes mellitus non-insulin dependent red blood cell membrane Na+-K+ -ATPase Ca~2+-Mg~2+-ATPase whole blood viscosity |
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| 中文摘要: |
| 目的：为探讨中药仙贞片改善糖尿病患者Ｎａ＋－Ｋ＋－ＡＴＰ酶、Ｃａ２＋－Ｍｇ２＋－ＡＴＰ酶活性的作用。方法：观察７２例气阴两虚、肾虚血瘀非胰岛素依赖型糖尿病（ＮＩＤＤＭ）患者（中药仙贞片组）治疗前后Ｎａ＋－Ｋ＋－ＡＴＰ酶、Ｃａ２＋－Ｍｇ２＋－ＡＴＰ酶、全血粘度、血糖及临床症状等的变化。结果：治疗组（中药仙贞片组）疗后Ｎａ＋－Ｋ＋－ＡＴＰ酶．Ｃａ２＋－Ｍｇ２＋－ＡＴＩ”酶活性升高，有显著性意义（Ｐ＜０．０１，Ｐ＜０．０５），全血粘度和临床症状有一定程度的改善，降低血糖的总有效率为空腹血糖（ＦＢＧ）７７．Ｓ％、餐后２ｈ血糖（２°ＰＢＧ）６９．４％；而对照组（安慰剂组）全血粘度及临床症状元显著改善，降低血糖的总有效率为ＦＢＧ．４１．７％、２°ＰＧＢ３８．９％。结论：仙贞片具有改善患者Ｎａ＋－Ｋ＋－ＡＴＰ酶、Ｃａ２＋－Ｍｇ２＋－ＡＴＰ酶活性，改善全血粘度，降低血糖及改善临床症状等作用，为仙贞片治疗气阴两虚、肾虚血瘀ＮＩＤＤＭ患者提供实验依据。 |
| 英文摘要: |
| To assess the effect of Xianzhen tablet in treating non-insulin dependent diabetes mellitus (NIDDM).Methods: Seventy-two cases of NIDDM patients with deficiency of both Qi and Yin, deficiency of the Kidney and blood stasis were selected, and the effects of treatment on Na+-K+ -ATPase, Ca2-Mg2+-ATPase, whole blood viscosity, blood sugar and clinical symptoms were observed. Results: After treatment, the treated group showed increased activities that were statistically significant of Na+-K+-ATPase and Ca2+-Mg2+-ATPase (P < 0. 01, P < 0.02) .The whole blood viscosity and symptoms showed improvement to an extent and the total effective rate of blood sugar lowering were as follows f fasting blood glucose(FBG) 77.8%, 2hr. postprandial plasma blood glucose (2hr. postprandial PBG)69.4%. Whereas, the placebo group showed no marked improvement in either whole blood viscosity or symptoms and the total effective rate of blood sugar lowering were FBG 41.7%, 2hr. postprandial PBG:38.9%. CONCLUSION: Xianzhen tablet is effective in improving the activities of Na+-K+-ATPase and Ca2+-Mg2-ATPase, as well as the whole blood viscosity , blood sugar lowering and in improving clinical symptoms, it could treat effectively NIDDM patients with deficiency of both Qi and Yin, deficiency of the Kidney and blood stasis. |
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