| 周鹏.优降糖和中成药渴乐宁胶囊联合治疗Ⅱ型糖尿病的临床研究[J].,1997,(1):29-31 |
| 优降糖和中成药渴乐宁胶囊联合治疗Ⅱ型糖尿病的临床研究 |
| Clinical Study of Glibenclamide in Combination with Kelening Treatment in Non-Insulin Dependent Diabetes Mellitus |
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| DOI： |
| 中文关键词: 优降糖 渴乐宁 Ⅱ型糖尿病 |
| 英文关键词:glibenclamide Kelening non-insulin dependent diabetes mellitus |
| 基金项目: |
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| 中文摘要: |
| 目的：为寻求治疗糖尿病安全有效的药物。方法：将６５例Ⅱ型糖尿病患者随机分为中西药组和优降糖组。中西药组服用优降糖和中成药渴乐宁胶囊，优降糖组单纯服用优降糖，连续治疗１２周。结果：中西药组空腹血糖、餐后２ｈ血糖及糖化血红蛋白较治疗前均有明显下降（Ｐ＜０．０１～Ｏ．００１）。中西药组空腹血糖下降幅度和优降糖组比较无显著性差异（Ｐ＞０．０５），但餐后２ｈ血糖和糖化血红蛋白下降幅度显著优于优降糖组（Ｐ均＜０．０５），并且比优降糖组更容易避免出现高胰岛素血症。中西药组优降糖用量及不良反应均明显少于优降糖组。结论：优降糖与渴乐中胶囊联合应用较单独应用优降糖更为有效安全。 |
| 英文摘要: |
| To asses the efficacy of combination therapy of glibenclamide and Kelening in treating the non-insulin dependent diabetes mellitus (NIDDM). Methods: Sixty-five patients with NIDDM were randomly divided into two groups. One group was treated with both glibenclamide and Kelening, the other with glibenclamide alone. Results: After treatment for 12 weeks, the levels of fasting blood glucose (FBG), postprandial blood glucose (PBG) and HBA,. were reduced significantly in glibenclamide-Kelening group. In both groups, the degree dropped of the levels of FBG were almost the same, but the levels of PBG and HBA,. in glibenclamide-Kelening group were reduced more significantly than those in glibenclamide group, and the incidence of hyperinsulinemia had dropped considerably. ConcluSion: glibenclamide in combination with Kelening in the treatment of NIDDM is more effective and less toxic, and the combination may reduce the dosage of glibenclamide in NIDDM. |
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