| 李淑梅,刘斌,陈海芬,宋伟.葛根素注射液对急性心肌梗塞患者血浆内皮素及肾素血管紧张素系统的影响[J].,1997,(6):339-341 |
| 葛根素注射液对急性心肌梗塞患者血浆内皮素及肾素血管紧张素系统的影响 |
| Effect of Puerarin on Plasma Endothelin,Renin Activity and Angiotensin Ⅱ in Patients with Acute Myocardial Infarction |
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| DOI： |
| 中文关键词: 葛根素 急性心肌梗塞 内皮素 肾素血管紧张素系统 |
| 英文关键词:Puerarin acute myocardial infarction endothelin renin-angiotensin system |
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| 中文摘要: |
| 目的：观察急性心肌梗塞（ａｃｕｔｅｍｙｏｃａｒｄｉａｌｉｎｆａｒｃｔｉｏｎ，ＡＭＩ）患者血浆内皮素（ｅｎｄｏｔｈｅｌｉｎ，ＥＴ）与肾素活性（ｒｅｎｉｎａｃｔｉｖｉｔｙ，ＲＡ）、血管紧张素Ⅱ（ａｎｇｉｏｔｅｎｓｉｎⅡ，ＡＴ－Ⅱ）的变化及葛根素对其影响。方法：将４３例ＡＭＩ患者分为两组，分别接受葛根素（２３例）及极化液（２０例）治疗，以放免法检测治疗前及治疗后不同时期血浆ＥＴ、ＲＡ及ＡＴ－Ⅱ活性的变化。结果：ＡＭＩ患者血浆ＥＴ、ＲＡ及ＡＴ－Ⅱ血活性明显高于健康对照组（Ｐ＜０．０１），且ＥＴ与ＲＡ及ＡＴ－Ⅱ间均存在着显著正相关（Ｐ＜０．０１）；经葛根素治疗后血浆ＥＴ及ＲＡ、ＡＴ－Ⅱ在３天内恢复至正常，而经极化液治疗组血浆ＲＡ及ＡＴ－Ⅱ于７天方恢复接近正常，ＥＴ在１４天才降至正常。结论：葛根素是对ＡＭＩ患者异常反应的神经内分泌系统有重要调节作用的药物。 |
| 英文摘要: |
| To study the changes of endothelin (ET), renin activity (RA) and angiotensin Ⅱ (AT-Ⅱ)before and after puerarin treatment in patients with acute myocardial infarction (AMI).Methods: Forty-three patients with AMI were divided into two groups,and were given puerarin and glucose-insulin-kalium(GIK) treatment respectively. Plasma ET, RA and AT-Ⅱ were measured by radioimmunoassay (RIA) before and after treatment in different phases. Results: It showed that plasma ET and RA, AT-Ⅱ levels in AMI were higher than those in control group (P<0.01 ). ET level was conversely correlated with RA and AT-Ⅱ (P< 0.01). After treatment with puerarin,plasma levels of ET,RA and AT-Ⅱ were recovered to normal in 3 days,but these data recovered to nearly normal until 7～14 days in group with GIK treatment. Conclusion: Puerarin might play an important role in regulating the imbalance of ET,RA and AT-Ⅱ of patients with AMI. |
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