| 史炜镔,张昊,杜宁,王济纬,符诗聪,杨建,曲克服,李国衡.骨松Ⅱ号治疗绝经后骨质疏松症临床生化指标观察[J].,1997,(7):398-400 |
| 骨松Ⅱ号治疗绝经后骨质疏松症临床生化指标观察 |
| Clinical Biochemical Observations on Treatment for Postmenopausal Osteoporosis with Gusong-Ⅱ |
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| DOI： |
| 中文关键词: 骨松Ⅱ号 绝经后骨质疏松症 生化指标 |
| 英文关键词:Gusong-Ⅱ postmenopausal osteoporosis biochemical marker |
| 基金项目: |
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| 中文摘要: |
| 目的：评估骨松Ⅱ号治疗绝经后骨质疏松症的疗效，并试图揭示其机理。方法：以３５例年龄４９～６２岁、绝经时间５．６年的绝经后骨质疏松症妇女为治疗对象，于治疗后６～９个月、１～２年分期随访。疗程６个月～２年１个月不等，平均疗程为１年２个月。治疗前后作血雌二醇（Ｅ２）、睾酮（Ｔ）、晨尿Ｃａ／Ｃｒ、２４ｈ尿Ｃａ／Ｃｒ、２４ｈ尿Ｅ２、２４ｈ尿羟脯氨酸（ＨＯＰ）等生化指标的测定。结果：治疗６～９个月及治疗１～２年后，血及２４ｈ尿Ｅ２显著升高，治疗１～２年后血Ｔ与尿Ｃａ／Ｃｒ显著下降。血Ｅ２、２４ｈ尿Ｅ２分别与晨尿Ｃａ／Ｃｒ、血Ｔ、２４ｈ尿Ｃａ／Ｃｒ、２４ｈ尿ＨＯＰ治疗前后变化值呈显著相关。结论：骨松Ⅱ号具有提高绝经后妇女血Ｅ２水平、降低尿Ｃａ／Ｃｒ及２４ｈ尿ＨＯＰ、抑制骨吸收的作用；其升高血Ｅ２水平的作用，可能与促进Ｔ向Ｅ２的转化有关。 |
| 英文摘要: |
| Objective:To evaluate the curative effect of Cusong Ⅱ for postmenopausal osteoporsis,and try to reveal its mechanism. Methods: Thirty-five women, 49 to 62 years old, with 5.6 years menopause were treated as the subjects and followed for 6～9 months, 1～2 years.The course of treatment ranged from 6 months to 2 years and 1 month, and the average treatment pened was 1 year and 2 months. Some related biochemical markers, such as serum estradiol (E2), testosterone (T), lasting morning urinary Ca/Cr, 24h urinary Ca/Cr,24h urinary E2, 24h urinary hydroxyproline (HOP), were measured before and after treatment. Results: After 6～9 months or 1～2 years, the levels of serum E2 and 24h urinary E2 were raised significantly, while the levels of serum T and urinary Ca/Cr reduced evidently after 1- or 2- year treatment. The levels of serum E2 and 24h urinary E2 were significantly correlated with levels of lasting morning urinary and 24h urinary Ca/Cr, serum T, 24h urinary HOP respectively.Conclusion: Gusong-Ⅱ could elevate the serum E2 levels of postmenopausal women, reduce the discharge of urinary Ca/Cr and HOP, inhibit the bone resorption. The rose of the serum E2 level might be correlated with the converison of T into E2. |
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