| 沈剑刚,郭志刚,佟丽,陈育尧,刘伊丽,贾满盈,陈素云,赵保路,忻文娟.益气通络丹对冠心病、高血压病氧自由基、一氧化氮含量及纤溶活性的影响[J].,1997,(7):410-413 |
| 益气通络丹对冠心病、高血压病氧自由基、一氧化氮含量及纤溶活性的影响 |
| Mechanisms of Yiqi Tongluo Pill on Oxygen Free Radicals, Nitric Oxide and Fibrinolysis in Coronary Heart Diseases and Hypertension Patients |
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| DOI： |
| 中文关键词: 益气通络丹 冠心病 高血压病 脂质过氧化 一氧化氮 组织型纤溶酶原激活物 |
| 英文关键词:Yiqi Tongluo Pill coronary heart disease hypertension lipid peroxidation nitric oxide tissuetype plasminogen activator |
| 基金项目:国家自然科学基金 |
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| 中文摘要: |
| 目的：阐明益气通络丹治疗冠心病、高血压病的疗效机制。方法：９７例冠心病、高血压病患者服用益气通络丹，观察临床疗效及其对血液脂质过氧化物（ＬＰＯ）含量、超氧化物歧化酶（ＳＯＤ）活性、一氧化氮（ＮＯ）含量及组织型纤溶酶原激活物（ｔ－ＰＡ）及其抑制物（ＰＡＩ）活性的影响；并与９２例硝酸酯类治疗的冠心病、高血压病患者和３０名健康人进行对比。结果：冠心病、高血压病患者血浆ＬＰＯ、ＰＡＩ水平显著升高，ＳＯＤ、ｔ－ＰＡ、ＮＯ水平显著降低。益气通络丹组治疗不稳定型心绞痛临床疗效优于硝酸酯类组，而治疗高血压病和高血压合并冠心病临床疗效较硝酸酯类组为差。进一步观察显示益气通络丹能显著降低冠心病患者血浆ＬＰＯ、ＰＡＩ水平，升高ＳＯＤ、ｔ－ＰＡ和ＮＯ水平，其中对ｔ－ＰＡ和ＳＯＤ的作用效果优于硝酸酯类对照组。而对高血压病患者血浆ＮＯ水平作用弱于硝酸酯类组。结论：益气通络丹的疗效机制与抑制脂质过氧化、保护内皮依赖性松弛因子和调节纤溶活性有关。 |
| 英文摘要: |
| Objective:To clarify the mechanism of Yiqi Tongluo Pill (YQTLP)in treating coronary heart disease and hypertension. Methods: The clinical effects of YQTLP on 97 coronary heart diseases (CHD) and hypertension patients, in cowing to the 92 patients treated with nitroglycerin was investigated. The changes of plasma lipid peroxide (LPO), superokide dismutase (SOD), tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor (PAI) and nitric chide (NO) were observed in the patients treated with YQTLP and nitroglycerin, which were compared to 30 healthy subjects. Results:The levels of LPO and PAI increased and the levels of SOD, t-PA and NO decreased significantly in the patients. The clinical effects of YQTLP were better than that of nitroglycerin in the patients with unstable angina, while the effects of YQTLP were worse than that of nitroglycerin in the patients Of hypertenSion and hypertenSion with CHD. YQTLP could decrease the levels of LPO and PAI and increase the levels of SOD, t - PA and NO significantly. The effects of YQTLP on t - PA and SOD were better than that of nitfoglycerin. Conclusion: The protective mechanisms of YQTLP were related to inhibit lipid peroxidation, protect endothelium-derived relaxing factor and adjust the fibrinolytic activities. |
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