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徐成钢,吴志英.益肾泻浊方血清对慢胜肾衰大鼠肾小球系膜细胞的影响[J].,1997,(7):423-424

益肾泻浊方血清对慢胜肾衰大鼠肾小球系膜细胞的影响

Effect of Yishen Xiezhou Recipe on Mesangium Cell of Chronic Renal Failure Rats

DOI：

中文关键词: 益肾泻浊方肾小球系膜细胞增殖

英文关键词:Yishen Xiezhuo Recipe glomerular mesangium cell proliferation

基金项目:国家自然基金

Author Name	Affiliation
徐成钢
吴志英

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中文摘要:

目的：观察益肾泻浊方对大鼠肾小球系膜细胞增殖的影响。方法：采用灌胃法给予健康大鼠及实验性慢性肾功能衰竭大鼠益肾泻浊方冲剂，观察给药后大鼠血清对肾小球系膜细胞增殖的影响。结果：与灌服生理盐水的对照大鼠相比较，前者能明显抑制系膜细胞的增殖（Ｐ＜０．０１）。结论：该方能延缓慢性肾功能衰竭进程。

英文摘要:

Objective:To observe the effect of Yishen Xiezhuo Recipe (YSXZR) on glomerular mesangium cell (MSC) proliferation. Methods: YSXZR was given to healthy and experimental CRF rats by gastrogavage, and the effect of their serum on MSC proliferation was observed. Results: The serum could obviously inhibit the MSC proliferation.Compared with control rats to which physiological saline was given, the difference was significant (P<0.01).Conclusion: YSXZR could postpone CRF progress.

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