| 陈少贤,王良兴,邢玲玲,吴兰豹,王明山.川芎嗪对晚期肺癌患者血小板功能的影响[J].,1997,(9):531-533 |
| 川芎嗪对晚期肺癌患者血小板功能的影响 |
| Effects of Tetramethylpyrazine on Platelet Functions of Advanced Cases of Lung Carcinoma |
| |
| DOI： |
| 中文关键词: 川芎嗪 肺癌转移 血栓素B2 6－酮－前列腺素F1α |
| 英文关键词:Tetramethylpyrazine metastasis of primary lung carcinome thromboxane B2 6-ketoprostaglandin F1α |
| 基金项目: |
|
| Hits: 1350 |
| Download times: 958 |
| 中文摘要: |
| 目的：探讨川芎嗪对晚期肺癌患者血小板功能的影响。方法：对２５例晚期肺癌患者和２６例健康对照者测定了血浆血栓素Ｂ２（ＴＸＢ２）、６－酮－前列腺素Ｆ１α（６－ｋｅｔｏ－ＰＧＦ１α）、凝血Ⅷ因子活性（Ⅷ∶Ｃ）、血管性假血友病因子（ｖＷＦ）、纤维蛋白原（Ｆｇ）、抗凝血酶Ⅲ活性（ＡＴ－Ⅲ∶ａ）、抗凝血酶Ⅲ抗原（ＡＴ－Ⅲ∶Ⅲ∶Ａｇ）及血小板粘附功能（ＰＡｄＴ）、血小板聚集功能（ＰＡｇＴ）。并对肺癌患者用川芎嗪（ｔｅｔｒａｍｅｔｈｙｌｐｙｒａｚｉｎｅ，ＴＴＭＰ）前后上述指标进行比较。结果：肺癌患者血ＴＸＢ２、６－ｋｅｔｏ－ＰＧＦ１α、Ⅷ∶Ｃ、ｖＷＦ及Ｆｇ显著升高（Ｐ＜０．０１），ＰＡｄＴ较对照组明显为低（Ｐ＜０．０５），ＰＡｇＴ、ＡＴ－Ⅲ∶ａ及ＡＴ－Ⅲ∶Ａｇ两组间无显著差异。肺癌患者用ＴＴＭＰ后，ＰＡｄＴ、ＰＡｇＴ、Ⅷ∶Ｃ、ｖＷＦ及Ｆｇ较用药前显著降低（Ｐ＜０．０１），ＴＸＢ２、６－ｋｅｔｏ－ＰＧＦ１α、ＡＴ－Ⅲ∶ａ及ＡＴ－Ⅲ∶Ａｇ无明显下降。结论：肺癌患者处于高凝状态，有利于肿瘤细胞转移。ＴＴＭＰ降低肺癌患者血小板粘附、聚集及凝血因子活性可能是其抗肿瘤转移作用机理之一，值得进一步探讨。 |
| 英文摘要: |
| To explore the role of hypercoagulation in the metastasis of carcinoma. Methods: The effect of Tetramethylpyrazine (TTMP) on platelet functions among the 25 advanced cases of lung carcinoma, and 26 matchedcontrol subjects were investigated in the study. Their ages varied from 31～86 years (mean 58. 2) in lung carcinoma group (13 male, 12 female) and 36 to 61 (mean 52. 9) in the control group (16 male, 10 female). The pathologic types were as follows: 7 cases of squamous cell cancer, 12 adenocarcinoma, 2 small cell carcinoma and 4 undistinguished type. The TNM stage revealed 14 cases in stage m a, 3 in stage ill b and & in stage Ⅳ. The site ofmetastasis included mediastinal lymph node, pleura, supraclavicular lymph node, brain, spine, costa, skin andpericardium. The levels of plasma TXB2, 6-keto-PGF1a,-Ⅷ: C, vWF, AT-Ⅲ: a, AT-Ⅲ: Ag, Fg and blood PAdT,PAgT were measured before and after the intravenous infusion of 80 mg TTMP in patients with lung carcinoma.Results: The levels of TXB2, 6-keto-PGF1a, Ⅷ: C, vWF and Fg in lung carcinoma group were significantly elevated, while the levels of PAdT was greatly decreased, compared with the control group, no significant differences inlevels of PAgT, AT- Ⅲ:a and AT-Ⅲ: Ag were found between the two groups. After the infusion of TTMP thelevels of PAdT, PAgT,Ⅷ: C, dWF and Fg were decreased significantly, while TXB2, 6-keto-PGF1a, AT- Ⅲ∶a andAT-Ⅲ: Ag remained unchanged. Conclusions: TTMP inhibits the adhesion and aggregatory functions of bloodplatelet and the activity of coagulation factors. It might be one of the mechanisms of TTMP’s antimetastasis of lungcarcinoma. |
| View Full Text View/Add Comment Download reader |
|
|
|
