| 蔡华芳,刘雪莉,钱伯初,陈凯,李兰妹,张永华,余逸波.桃蛭枳朴冲剂对大鼠实验性肠粘连的预防作用及其治疗机理的研究[J].,1997,(10):603-606 |
| 桃蛭枳朴冲剂对大鼠实验性肠粘连的预防作用及其治疗机理的研究 |
| Effect of Taozhi Zhipo Granule on Intestinal Adhesion in Rats and Exploration of Its Therapeutic Mechanism |
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| DOI： |
| 中文关键词: 桃蛭枳朴冲剂 肠粘连 动物模型 |
| 英文关键词:Taozhi Zhipo Granule intestinal adhesion animal model |
| 基金项目:国家中医药管理局科研基金 |
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| 中文摘要: |
| 目的：探讨桃蛭枳朴冲剂预防肠粘连的作用机理。方法：选用ＳＤ雄性大鼠，手术造成肠粘连模型，每日灌胃桃蛭枳朴冲剂１０、２０ｇ／ｋｇ，连续１２天。结果：该药可使大鼠肠粘连程度减轻，平均粘连长度降低。此外，实验还证明桃蛭枳朴冲剂能延长小鼠断尾出血时间和豚鼠血浆复钙时间，改善小鼠耳廓微循环，提高小鼠小肠炭末推进率，对大鼠离体回肠有轻度的兴奋作用，能抑制小鼠腹腔毛细血管通透性和巴豆油所致耳廓肿胀，并能提高小鼠腹腔巨噬细胞的吞噬功能。结论：桃蛭枳朴冲剂对肠粘连有一定的预防作用，其作用机理可能是通过改善局部组织的缺血状况，提高肠蠕动功能，减少炎症渗出，使腹腔内渗出物及时吸收，从而起到预防肠粘连的作用。 |
| 英文摘要: |
| Objective: To explore the therapeutical mechanism of Taozhi Zhipo Granule(TZZPG)on intestinal adhesion.Methods: Fed SD male rats of intestinal adhesion model with TZZPG 10, 20g/kg·d continuously for 12 days. Results:TZZPG could alleviate the degree and the average length of intestinal adhesion in rats. It also could prolong bleeding time in mice and plasma recuperation time of guinea-pigs, improve the auricular microcirculation in mice,accelerate the removing speed of charcoal powder in mice’s intestine and slightly strengthen the contraction of rat intestine in vitro. TZZPG relieved the croton oil topical edema of ear and reduced the capillary permeability of abdominal cavity in mice. TZZPG could enhance the phagocytosis of peritoneal macrophages. Conclusions: TZZPG has preventive effect on intestinal adhesion. The action might be due to improve the ischemia in local tissue, strengthen the contraction of intestine and inhibit the inflammation. |
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