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Author Name	Affiliation
李自成	湖北医科大学附属第一医院心内科
李庚山	湖北医科大学附属第一医院心内科
黄从新	湖北医科大学附属第一医院心内科
许家琍	湖北医科大学附属第一医院心内科

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中文摘要:

目的：观察大蒜素对培养的兔主动脉平滑肌细胞（ＳＭＣ）增殖细胞核抗原（ＰＣ－ＮＡ）表达的影响。方法：用免疫组化ＬＳＡＢ法检测ＳＭＣ的ＰＣＮＡ表达，同时测定培养液中超氧化物歧化酶（ＳＯＤ）、脂质过氧化物（ＬＰ）、前列环素（ＰＧＩ２）及环磷酸腺苷（ＣＡＭＰ）的含量。结果：大蒜素能增加ＳＯＤ活性，降低ＬＰＯ，升高ＰＧＩ２和ｃＡＭＰ水平，抑制ＳＭＣ的ＰＣＮＡ表达（Ｐ＜０．０５～０．０１）。结论：大蒜素有抑制ＳＭＣ增殖的作用。

英文摘要:

Objective:To observe the effect of allitridi on the expression of proliferating cell nuclear antigen (PCNA)of cultured rabbit aortic smooth muscle cell(SMC). Methods: The expression of PCNA was examined with immunohistochemical technique(LSAB method) and the contents of superoxide dismutase (SOD), lipid peroxide (LPO),prostacyclin (PGI2) and cyclic adenosine monophosphate(cAMP) in medium were simultaneously determined. Resuls: Allitridi has the effects of increasing SOD activity, decreasing LPO, elevating PGI2 and cAMP, reducing the expression of PCNA (all P < 0. 05 - 0. 01 ). Conclusion: Allitridi could inhibit SMC proliferation.

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