| 刘礼意,孙兆泉,向华,唐湘涓,应玲珍,刘敏,杨旭光,首弟武,刘天舒.益气活血方对老年大鼠神经免疫调节影响的研究[J].,1997,(10):616-619 |
| 益气活血方对老年大鼠神经免疫调节影响的研究 |
| Studies on Neuro-immunologic Regulation of Senile Rats by Using the Princlple of Replenishing Qi and Promoting Blood Circulation |
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| DOI： |
| 中文关键词: 衰老 神经免疫调节 益气活血方 大鼠 |
| 英文关键词:senility neuro-immunologic regulation the principle of replenishing θiand promoting blood circulation rat |
| 基金项目:国家自然科学基金 |
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| 中文摘要: |
| 目的：探讨益气活血方延缓衰老的机理。方法：利用自然衰老气虚血瘀证大鼠，观察给予益气活血方前后血液流变性；大脑去甲肾上腺素（ＮＥ）；血促肾上腺皮质激素（ＡＣＴＨ）、β－内啡肽（β－Ｅｎｄ）、皮质醇（Ｃｏｒｔｉｓｏｌ）、雌二醇（Ｅ２）、睾酮（Ｔ）、白细胞介素－Ⅱ（ＩＬ－２）、肿瘤坏死因子（ＴＮＦ）；脾淋巴细胞转化，诱生ＩＬ－２及自然杀伤细胞（ＮＫＣ）活性。结果：与青年鼠比较，衰老大鼠上述指标值均有不同程度降低，应用益气活血方治疗，衰老大鼠上述指标得到明显改善，而对青年鼠无明显影响。结论：益气活血方可有效增强衰老机体神经、内分泌、免疫调节功能，维持机体内环境稳定。 |
| 英文摘要: |
| Objective: To study the mechanism of delaying senility by using the principle of replenishing Qi and promoting blood circulation(RQPBC). Methods: The following determinations were carried out in the natural-senile animals which have Qi deficiency and blood stasis Syndrome(24 month old rat) after the treatment. Hemorheological indexes, brain noradrenaline (NE), adrenocorticotropine(ACTH), β endorphin, cortisol, estradiol, testoderone, interleukin-Ⅱ (IL-2), tumour necrosis factor (TNF) in the blood, and rat spleen’s lymphocyte transformation and induction of IL-2 and the activity of natural killer cells (NKC). Results: The senile rat’s above indexes decreased obviously (control: young rats), and by using this principle, all indexes were improved respectively. But these indexes in the young rats cannot be changed by applying this principle. Conclusion: The results indicated that this principle could improve senile body’s reguilation of neuro-immuno-endocrinologic network and keep homeostasis. |
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