| 刘树硕,杨永华,王泽时.叶绿素光敏剂光动力疗法预防浸润性膀胱癌术后复发的临床研究[J].,1998,(1):15-17 |
| 叶绿素光敏剂光动力疗法预防浸润性膀胱癌术后复发的临床研究 |
| Clinical Study of CPD4-PDT for the Prevention of Postoperative Recurrence in Infiltrative Bladder Cancer |
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| DOI： |
| 中文关键词: 膀胱肿瘤 叶绿素光敏剂 光动力疗法 |
| 英文关键词:bladder cancer chlorophyll derivative photedynamic therapy |
| 基金项目: |
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| 中文摘要: |
| 目的：为评价叶绿素光敏剂光动力疗法（ＣＰＤ４－ＰＤＴ）预防浸润性膀胱癌术后复发的疗效。方法：３２例浸润性膀胱癌术后患者接受叶绿素光敏剂光动力疗法，并均接受随访。结果： Ｔ２期组与 Ｔ３期组复发率无显著性差异（ ４２．１％和 ６９．２％， Ｐ＞ ０．０５）。单发肿瘤与多发肿瘤复发率亦无显著性差异（４４．４％和 ６４．３％，Ｐ＞０．０５）。Ｔ２期和Ｔ３期组患者无瘤生存时间（月）分别为１９．８０±１４．８０和２２．６７±１９．７２（Ｐ＞０．０５）。病理分级为Ⅰ级与Ⅱ、Ⅲ级组的复发率（０和６６．７％，）有明显差异（Ｐ＜０．００１）。结论：叶绿素光敏剂光动力疗法是一种安全有效地预防膀胱肿瘤术后复发的手段之一。 |
| 英文摘要: |
| Objectly: To assess the efficacy of chlorophyll derivative （CPD4 ） - Photodynamic therapy （PDT ） in preventing postoperative recurrence of the infiltrative cancer of the urinary bladder. Methods: Thirty-two patients were treated with CPD4-PDT postoperationally to prevent the recurrence of cancer, all of which being followed up. Results: The recurrence rate was 42.1 % in T2 tumors and 69.2 % in T3 tumors （P < 0. 05）, and the surival period without tumor has been 19.8 ± 14.8 months in T2 tumors, and 22.67 ±19.72 months in T3 tumors （P >0.05）. There was very significant difference in recurrent rate between grade Ⅰ and grade Ⅱ、Ⅲ patients （0 and 66. 7 %, P< 0. 001 ）. Conclusion:CPD4-PDT is a safe and effective measure to prevent the recurrence in infiltrative bladder cancer after Operation. |
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