| 杜秀兰,张宏,傅新利,张之澧,张梅涧,马永祯.雷络酯片治疗类风湿性关节炎的临床研究[J].,1998,(2):88-91 |
| 雷络酯片治疗类风湿性关节炎的临床研究 |
| Clinical Study on Tripterygium Wilfordii Complex Ester Tablet in Treating Rheumatoid Arthritis |
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| DOI： |
| 中文关键词: 雷络酯片 雷公藤多甙片 类风湿关节炎 |
| 英文关键词:Tripterygium Wilfordii Complex Ester Tablet Tripterygium Wilfordii Polycoside Tablet rheumatoid arthritis |
| 基金项目: |
| Author Name | Affiliation | | 杜秀兰 | Du Xiulan, Zhang Hong, Fu Xinli, et al (Affiliated Hospital of Shandong Traditional Chinese Medical University, Jinan (250011 | | 张宏 | Du Xiulan, Zhang Hong, Fu Xinli, et al (Affiliated Hospital of Shandong Traditional Chinese Medical University, Jinan (250011 | | 傅新利 | Du Xiulan, Zhang Hong, Fu Xinli, et al (Affiliated Hospital of Shandong Traditional Chinese Medical University, Jinan (250011 | | 张之澧 | Du Xiulan, Zhang Hong, Fu Xinli, et al (Affiliated Hospital of Shandong Traditional Chinese Medical University, Jinan (250011 | | 张梅涧 | Du Xiulan, Zhang Hong, Fu Xinli, et al (Affiliated Hospital of Shandong Traditional Chinese Medical University, Jinan (250011 | | 马永祯 | Du Xiulan, Zhang Hong, Fu Xinli, et al (Affiliated Hospital of Shandong Traditional Chinese Medical University, Jinan (250011 |
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| 中文摘要: |
| 观察雷公藤叶制剂──雷络酯片治疗类风湿性关节炎的疗效和毒副作用。方法：采用前瞻性、多中心、随机双盲对照的方法，共观察类风湿性关节炎２７７例，治疗组１４０，口服雷络酯片，每次２片，每天３次；对照组１３７例，口服雷公藤根制剂──雷公藤多甙片，每次 ２片，每天 ３次，均 ６周为 １个疗程。结果：治疗组愈显率 ２５． ７１％，总有效率为８６． ４３％；对照组愈显率 ２６． ２８％，总有效率为 ８３． ９４％，两组比较无显著性差异（Ｐ＞０． ０５）。不良反应的发生率治疗组为 ２０． ００％，对照组为 ２３． ３５％，两组比较无显著性差异（Ｐ＞０． ０５）。结论：雷公藤叶制剂的有效性及安生性均同于根制剂。 |
| 英文摘要: |
| To observe the curative effect, toxic and side effect of Tripterygium Wilfordii Complex Ester Tablet (TWT, a preparation of Folium Tripterygium wilfordii) in treating rheumatoid arthritis. Methods: Two hundred and seventy seven patients were observed with prospective, multicentric and random double-blind control method. One hundred and forty cases of TWT group were treated with TWT 2 tablets each time, 3 times a day orally, and the other 137 cases treated with Tripterygium Wilfordii Polycoside Tablet (TPT, a preparation of Radix Tripterygium Wilfordii) 2 tablets each time were taken as control, 3 times a day orally. The therapeutic course for both groups was 6 weeks. Results: The markedly controlled rate of the TWT group was 26. 71% and the total effective rate was 86.43%, while those in the control group were 26. 28% and 83. 94% respectively, the difference between the two groups was insignificant (P>0.05). The occurrence of side-effect in the two groups was 20.00% and 23.35% respectively, also showed no significant difference (P>0.05). Conclusion: The Folium Tripterygium Wilfordii preparation is similar in efficacy and security to the Radix Tripterygium Wilfordii preparation. |
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