| 彭康.乌龙丹治疗急性脑梗塞及对下丘脑—垂体—甲状腺轴内分泌激素变化的影响[J].,1998,(3):135-137 |
| 乌龙丹治疗急性脑梗塞及对下丘脑—垂体—甲状腺轴内分泌激素变化的影响 |
| Effect of Wulong Dan on Treatment of Acute Cerebral Infarction and Change of Hormones in Hypothalamus Pituitary Thyroid Axis |
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| DOI： |
| 中文关键词: 乌龙丹 急性脑梗塞 治疗作用 |
| 英文关键词:Wulong Dan acute cerebral infarction therapeutic effect |
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| 中文摘要: |
| 目的 :通过对 66例急性脑梗塞住院患者进行了较系统的临床观察和有关下丘脑—垂体—甲状腺轴内分泌激素水平的检测 ,以探讨中药复方乌龙丹的临床疗效和有关机制。方法 :临床疗效评定采用计分法 ,治疗组 (3 5例 )用低分子右旋糖酐静脉滴注加乌龙丹口服。对照组 (3 1例 )用低分子右旋糖酐静脉滴注加尼莫通口服 ,疗程均为 4周 ,治疗前后采血用放免法检查 :三碘甲状腺原氨酸 (T3)、甲状腺素 (T4)、游离三碘甲状腺原氨酸 (FT3)、游离甲状腺素(FT4)、促甲状腺素 (TSH)。结果 :治疗组疗效优于对照组 ,疗效评分值增加 ;经 4周治疗用药后 ,治疗组的T3、FT3和TSH由治疗前的较低水平升高至正常范围 ,两组用药前后各指标变化差值比较 ,在T3、FT3、TSH有显著性差异 (P <0 0 1 )。结论 :本研究表明了中药乌龙丹在低分子右旋糖酐改善微循环作用的基础上发挥了更有效的治疗作用 ,对脑梗塞急性期下丘脑—垂体—靶腺轴功能紊乱、激素分泌异常有一定的调节作用 ,从而有助于维持内环境的相对稳定。 |
| 英文摘要: |
| Objective: To explore the effect of Wulong Dan (WLD) on treatment of acute cerebral infarction and change of hormones in hypothalamus pituitary thyroid axis. Methods: Thirty five cases of the treated group treated with WLD by taken orally and 31 cases of the control group treated with nimoton taken orally. And dextran was given intravenously to both groups. Blood level of triiodothyronine (T 3), free triiodothyronine (FT 3), thyroxine (T 4), free thyroxine (FT 4) and thyroid stimulating hormone (TSH)of all patients were determined before and after treatment by radioimmunoassay.Results: After 4 weeks of treatment, there were significant difference between the treated group and the control group in cure rate, markedly effective rate, cure score and disappearance of clinical symptoms (P<0 01). The levels of T 3, FT 3, TSH of all patients were lower than those of the normal control before treatment. After treatment with WLD and dextran, the above mentioned indexes turned to normal.Conclusions: WLD has a significant effect on patients with cerebral infarction on the basis of improved microcirculation induced by dextran.It also has regulatory effect on the hypothalamus pituitary thyroid axis disorder so as to be helpful in maintaining the homeostasis. |
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