| 黄瑞健,廖崇先,陈道中,陈为民,翁钦永.川芎嗪对先天性心脏病肺动脉高压体外循环下血栓素A2及前列环素的影响[J].,1998,(6):333-335 |
| 川芎嗪对先天性心脏病肺动脉高压体外循环下血栓素A2及前列环素的影响 |
| Effects in Tetramethylpyrazine on TXA2 and PGI2 by Cardio Pulmonary Bypass in Congenital Heart Diseases with Pulmonary Hypertension Patients |
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| DOI： |
| 中文关键词: 川芎嗪 体外循环 血栓素A2 前列环素 肺动脉高压 |
| 英文关键词:tetramethylpyrazine cardiopulmonary bypass thromboxane A 2 prostacyclin pulmonary hypertension |
| 基金项目: |
| Author Name | Affiliation | | 黄瑞健 | Huang Ruijian, Liao Chongxian, Chen Daozhong, et al Department of Thoracic and Cardiovascular Surgery, First Affiliated Hospital, Fujian Medical University, Fuzhou (350005 | | 廖崇先 | Huang Ruijian, Liao Chongxian, Chen Daozhong, et al Department of Thoracic and Cardiovascular Surgery, First Affiliated Hospital, Fujian Medical University, Fuzhou (350005 | | 陈道中 | Huang Ruijian, Liao Chongxian, Chen Daozhong, et al Department of Thoracic and Cardiovascular Surgery, First Affiliated Hospital, Fujian Medical University, Fuzhou (350005 | | 陈为民 | Huang Ruijian, Liao Chongxian, Chen Daozhong, et al Department of Thoracic and Cardiovascular Surgery, First Affiliated Hospital, Fujian Medical University, Fuzhou (350005 | | 翁钦永 | Huang Ruijian, Liao Chongxian, Chen Daozhong, et al Department of Thoracic and Cardiovascular Surgery, First Affiliated Hospital, Fujian Medical University, Fuzhou (350005 |
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| 中文摘要: |
| 目的 :探讨川芎嗪对先天性心脏病肺动脉高压患者体外循环下血栓素A2(TXA2 ) /前列环素 (PGI2 )平衡的保护作用。方法 :将 3 0例非紫绀型先天性心脏病肺动脉高压患者随机分为对照组 (1 5例 )和用药组 (1 5例 )。川芎嗪分别于麻醉诱导后静脉滴注 3mg/kg及转流后加入氧合器中 1mg/kg ,分别于麻醉诱导后、转流 1 5min、升主动脉开放 5min、停机后2 0min、6h及 2 4h采血并测定TXA2 、PGI2 。结果 :用药组与对照组比较 ,除术前、停机后 2 4h外 ,其余各时点均有显著性差异 (P <0 0 1 )。结论 :川芎嗪能纠正先天性心脏病肺动脉高压患者体外循环下TXA2 、PGI2 的失衡。 |
| 英文摘要: |
| Objective: To study protective effects of tetramethylpyrazine (TMP) on the imbalance of TXA 2/PGI 2 during cardiopulmomary bypass (CPB) in congenital heart disease (CHD) with pulmonary hypertension (PH) patients. Methods: Thirty patients suffered from non cyanotic CHD PH were randomly divided into control group (n=15) and treatment group (n=15). 3 mg/kg of TMP was dripped intravenously after anesthesia and 1 mg/kg of TMP was infused into oxygenator after CPB individually. Blood samples were collected and TXA 2 as well as PGI 2 were measured after anesthesia induction, 15 min during CPB, 5 min after release of the aortic cross clamp,and 20 min, 6 hrs and 24 hrs after CPB. Results: There was significant difference between treatment group and control group except before operation and 24 hrs after CPB. Conclusions: The imbalance of TXA 2 and PGI 2 in patients with CHD PH during CPB could correct by TMP. |
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