| 康颂建,曾兆麟,史献君,李亚鲁.电针对庆大霉素耳中毒豚鼠耳蜗内琥珀酸脱氢酶的影响[J].,1998,(6):362-364 |
| 电针对庆大霉素耳中毒豚鼠耳蜗内琥珀酸脱氢酶的影响 |
| Effect of Electroacupuncture on Succinate Dehydrogenase of Gentamycin Induced Ototoxic Cochlear Hair Cells in Guinea Pigs |
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| DOI： |
| 中文关键词: 电针疗法 庆大霉素 耳毒性 琥珀酸脱氢酶 |
| 英文关键词:electroacupuncture therapy gentamycin ototoxicity succinate dehydrogenase |
| 基金项目:国家自然科学基金资助课题!(No .39470 86 9) |
| Author Name | Affiliation | | 康颂建 | Kang Songjian, Zeng Zhaolin, Shi Xianjun, et al Department of Physiology, Taishan Medical College, Shandong (271000 | | 曾兆麟 | Kang Songjian, Zeng Zhaolin, Shi Xianjun, et al Department of Physiology, Taishan Medical College, Shandong (271000 | | 史献君 | Kang Songjian, Zeng Zhaolin, Shi Xianjun, et al Department of Physiology, Taishan Medical College, Shandong (271000 | | 李亚鲁 | Kang Songjian, Zeng Zhaolin, Shi Xianjun, et al Department of Physiology, Taishan Medical College, Shandong (271000 |
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| 中文摘要: |
| 目的 :观察电针对豚鼠庆大霉素 (gentamicin ,GE)耳中毒引起的耳蜗琥珀酸脱氢酶 (succinatedehydrogenase ,SDH)变化的影响。方法 :将动物随机分成 3组 :GE组动物肌肉注射GE80mg·kg- 1 ·d- 1 ,连续注射 2 0天 ;针刺组肌肉注射GE同GE组 ,每天电针双侧听宫、翳风、肾俞穴 1次 ,持续刺激 1 5min ;对照组动物不做任何处理。以脑干听觉诱发电位 (BAEP)、SDH组织化学检测为观察指标。结果 :对照组BAEP和SDH两项指标无明显变化 ;GE组BAEP反应阈明显升高 ,SDH显色变淡或消失 ,毛细胞受损显著 ;针刺组BAEP反应阈升高幅度和SDH变化及毛细胞损害程度均明显低于GE组。结论 :针刺能减轻GE耳毒性 ,对SDH有保护作用。 |
| 英文摘要: |
| Objective: To observe the effect of electroacupuncture (EA) on succinate dehydrogenase (SDH) of gentamycin (GE) induced ototoxic cochlear hair cells. Methods: Preyer’s reflex normal guinea pigs were selected and divided randomly into three groups: GE group, EA group, control group. Brainstem auditory evoked potential (BAEP) and SDH in the cochlear hair cells were taken as indexes. In the animals of GE group GE was alone injected intramuscularly 80 mg·kg -1 ·d -1 for 20 days, while in the animals of EA group GE and additional EA was applied once a day on Tinggong(SI.19), Yifeng(SJ17) and Shenshu (UB23)points. EA lasted for 15 minutes. Results: In the GE group BAEP reaction threshold rose markedly, while that rose slightly in EA group. The difference was significant between two groups (P<0 05). The change of SDH within cochlear hair cells and degree of hair cells injury in the EA group were lower than those in GE group. Conclusions: EA therapy could relieve GE ototoxicity, protect SDH in cochlear hair cells and might be a possible mechanism of action of EA. |
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