| 林慧娟,王翠萍,郭伟星,包培蓉,蔡爱华.强心灵流浸膏治疗充血性心力衰竭的临床研究[J].,1998,(8):468-471 |
| 强心灵流浸膏治疗充血性心力衰竭的临床研究 |
| Clinical Study on Qiangxinling Liquid Extract in Treating Congestive Heart Failure |
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| DOI： |
| 中文关键词: 强心灵流浸膏 充血性心力衰竭 左心室功能 神经内分泌因子 |
| 英文关键词:Qiangxinling liquid extract congestive heart failure left ventricular function neuro endocinal factor |
| 基金项目:山东省卫生厅资助课题 |
| Author Name | Affiliation | | 林慧娟 | Lin Huijuan, Wang Cuiping, Guo Weixing, et al The Affiliated Hospital of Shandong University of TCM, Jinan (250011 | | 王翠萍 | Lin Huijuan, Wang Cuiping, Guo Weixing, et al The Affiliated Hospital of Shandong University of TCM, Jinan (250011 | | 郭伟星 | Lin Huijuan, Wang Cuiping, Guo Weixing, et al The Affiliated Hospital of Shandong University of TCM, Jinan (250011 | | 包培蓉 | Lin Huijuan, Wang Cuiping, Guo Weixing, et al The Affiliated Hospital of Shandong University of TCM, Jinan (250011 | | 蔡爱华 | Lin Huijuan, Wang Cuiping, Guo Weixing, et al The Affiliated Hospital of Shandong University of TCM, Jinan (250011 |
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| 中文摘要: |
| 目的 :为研究治疗充血性心力衰竭安全有效的药物和方法。方法 :对充血性心力衰竭心功能分级属Ⅲ～Ⅳ级的 90例患者随机分为 3组 ,每组 3 0例。A组服用强心灵流浸膏 ,B组服用强心灵流浸膏加小剂量地高辛 ,C组服用地高辛。结果 :心功能疗效 ,A组总有效率为 86 7% ,B组为 93 3 % ,C组为 83 3 % ,B组疗效优于A组及C组 (P <0 0 5 ,P <0 0 1 )。地高辛停减率 ,B组为 86 7% ,C组为 5 0 0 % ,两组比较有显著性差异 (P <0 0 5 )。A、B、C组治疗前后比较 ,均可改善左室收缩功能指标 ,包括每搏输出量 (SV)、每分钟心输出量 (CO)、射血分数 (EF) ,其中B组作用显著 (P <0 0 5 ,P <0 0 1 )。A、B组治疗前后比较 ,具有改善左室舒张功能作用 ,即改善舒张晚期最大血流速度 (A)、舒张早期最大血流速度 (E)、舒张晚期与舒张早期最大血流速度之比 (A/E)的作用 (P <0 0 5 ,P <0 0 1 )。A、B组治疗后血浆肾素活性(PRA)、血管紧张素Ⅱ (AngⅡ )、心钠素 (ANF)含量浓度与C组比较 ,亦有显著性差异 (P <0 0 5 ,P <0 0 1 )。结论 :强心灵流浸膏可改善心功能、临床症状和神经内分泌指标 ,并可降低洋地黄的毒副作用。 |
| 英文摘要: |
| Objective: To find the safe and effective treatment and drugs for congestive heart failure (CHF). Methods: Ninety CHF patients whose heart function belong to Ⅲ-Ⅳ grade were randomly divided into 3 groups: Group A was treated with Qiangxinling liquid extract (QXLLE); Group B with QXLLE plus small dose of digoxin and Group C with digoxin alone. Results: The total effective rate on heart function of Group A was 86.7%, Group B 93.3% and Group C 83.3%, the effect of Group B was better than that of the other two groups (P<0 05,P<0 01). The digoxin withdrawing and reducing rate in Group B was higher than that in Group C (86.7% vs 50 0%, P<0 05). The left ventricular systolic function, including stroke volume ,cardiac output, ejection fraction of the 3 groups were improved after treatment, among them the effect of Group B was the best (P<0 01). Moreover, improvement in ventricular diastolic function was shown in Group A and B, including the maximum blood flow of the late and the early diastolic stage as well as the ratio of them (P<0 05,P<0 01). The plasma renin activity, angiotensin Ⅱ and atrial natriuretic peptide of Group A and B were also lowered after treatment and were significantly different to those of the Group C (P<0 01). Conclusions: QXLLE could improve the heart function, clinical symptoms and neuro endocrinal indexes of CHF patients and reduce the side effects of digoxin. |
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