| 罗心平,李勇,范维琥,张高峰,张军,施海明,王彩萍,王受益,戴瑞鸿.麝香保心丸减少高脂血症对动脉壁损害作用的实验研究[J].,1998,(8):486-489 |
| 麝香保心丸减少高脂血症对动脉壁损害作用的实验研究 |
| Experimental Study on Reducing Effect of Shexiang Baoxin Pill from Damage of Arterial Wall Caused by Hyperlipemia |
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| DOI： |
| 中文关键词: 麝香保心丸 高胆固醇血症 动脉粥样硬化 超氧化物歧化酶 |
| 英文关键词:Shexiang Baoxin Pill hypercholesterolemia atherosclerosis superoxide dismutase |
| 基金项目: |
| Author Name | Affiliation | | 罗心平 | Luo Xinping, Li Yong, Fan Weihu, et al Huashan Hospital, Shanghai Medical University, Shanghai (200040 | | 李勇 | Luo Xinping, Li Yong, Fan Weihu, et al Huashan Hospital, Shanghai Medical University, Shanghai (200040 | | 范维琥 | Luo Xinping, Li Yong, Fan Weihu, et al Huashan Hospital, Shanghai Medical University, Shanghai (200040 | | 张高峰 | Luo Xinping, Li Yong, Fan Weihu, et al Huashan Hospital, Shanghai Medical University, Shanghai (200040 | | 张军 | Luo Xinping, Li Yong, Fan Weihu, et al Huashan Hospital, Shanghai Medical University, Shanghai (200040 | | 施海明 | Luo Xinping, Li Yong, Fan Weihu, et al Huashan Hospital, Shanghai Medical University, Shanghai (200040 | | 王彩萍 | Luo Xinping, Li Yong, Fan Weihu, et al Huashan Hospital, Shanghai Medical University, Shanghai (200040 | | 王受益 | Luo Xinping, Li Yong, Fan Weihu, et al Huashan Hospital, Shanghai Medical University, Shanghai (200040 | | 戴瑞鸿 | Luo Xinping, Li Yong, Fan Weihu, et al Huashan Hospital, Shanghai Medical University, Shanghai (200040 |
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| 中文摘要: |
| 目的 :观察麝香保心丸能否减少高脂血症对动脉壁的损害作用。方法 :喂饲胆固醇饲料 8周形成实验性高胆固醇血症 ,部分动物于第 7周开始加用麝香保心丸喂养 2周 ;在不同的时间测量动物血脂浓度、心电图改变、血清超氧化物歧化酶 (SOD)水平、动脉壁的光镜及电镜改变 ,以说明麝香保心丸对动脉血管壁的保护作用。结果 :麝香保心丸能显著抑制血清总胆固醇 (TC)、低密度脂蛋白胆固醇 (LDL -C)水平的上升 ;增加血清SOD的浓度 ,减轻高脂血症对动脉壁的损害 ,降低动脉内膜的增生。结论 :麝香保心丸对实验性动脉粥样硬化的形成有抑制作用。 |
| 英文摘要: |
| Objective: To study the protecting effect of Shexiang Baoxin Pill (SXBXP) on arterial wall in hyperlipemia rabbit model. Methods: Thirty six male, New Zealand rabbits were randomized into three groups: control group, fed with common diet for 8 weeks: Hypercholesterolemia group (HC) and SXBXP group (SX), fed with 1% cholesterol and 3% lard diet for 8 weeks. In SX group, SXBXP was iven from 7th week for 2 weeks. The plasma levels of triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) were measured at the first, 6th and the 8th week of experiment. Serum superoxide dismutase (SOD) and electrocardiography (ECG) were also evaluated at the 8th week. Light microscopy and transmission electron microscopy were adopted to assess the degree of pathologic damage of arterial wall. Results: SXBXP could reduce the levels of serum TC and LDL-C, as compared with the HC group, P<0 05. It could also reduce the extent of atherosclerotic lesion and the severity of intimal proliferation. Conclusion: SXBXP has the effect of inhibiting developement of experimental atherosclerosis. |
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