| 吴玉生,杨剑辉,姜立平,王占奎.补阳还五汤对原发性肾病综合征患者血浆血栓素B2、6-酮-前列腺素F1α、内皮素、降钙素基因相关肽改善作用的研究[J].,1998,(12):715-717 |
| 补阳还五汤对原发性肾病综合征患者血浆血栓素B2、6-酮-前列腺素F1α、内皮素、降钙素基因相关肽改善作用的研究 |
| Clinical Study on Improving Effect of Buyang Huanwu Decoction on Plasma Thromboxane B2, 6-Keto-Prostaglandin F1α, Endothelin and Calcitonin Gene Related Peptide in Primary Nephrotic Syndrome Patients |
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| DOI： |
| 中文关键词: 肾病综合征 补阳还五汤 血栓素B2 6-酮-前列腺素F1α 内皮素 降钙素基因相关肽 |
| 英文关键词:Buyang Huanwu Decoction primary nephrotic syndrome thromboxane B 2 6 keto prostaglandin F 1α endothelin calcitonin gene related peptide |
| 基金项目: |
| Author Name | Affiliation | | 吴玉生 | Wu Yusheng, Yang janhui, Jiang Liping, et al General Hospital of Jinan Military Region, Jinan (250031 | | 杨剑辉 | Wu Yusheng, Yang janhui, Jiang Liping, et al General Hospital of Jinan Military Region, Jinan (250031 | | 姜立平 | Wu Yusheng, Yang janhui, Jiang Liping, et al General Hospital of Jinan Military Region, Jinan (250031 | | 王占奎 | Wu Yusheng, Yang janhui, Jiang Liping, et al General Hospital of Jinan Military Region, Jinan (250031 |
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| 中文摘要: |
| 目的 :探讨补阳还五汤对原发性肾病综合征治疗机理。方法 :在强的松与环磷酰胺治疗原发性肾病综合征基础上 ,西药组 (3 5例 )用阿斯匹林与潘生丁、中西药结合组 (3 5例 )用补阳还五汤进行抗凝对比治疗 ,动态观察治疗前、首次减强的松剂量时 ,开始服强的松维持量时、总疗程结束时血浆血栓素B2 (TXB2 )、6 酮 前列腺素F1α(6 Keto PGF1α)、内皮素 (ET)、降钙素基因相关肽 (CGRP)水平及临床疗效 ,并与 3 0例健康人对照。结果 :上述 4项指标在治疗前与健康人有显著性差异 (P <0 0 0 1 ) ;在治疗过程中 ,4项指标改善与临床进步呈同步相关性 ;治疗结束时 ,中西药结合组 4项指标的改善均优于西药组 (P <0 0 1 ,P <0 0 0 1 ) ,并且中西药结合组完全缓解率也优于西药组 (62 9%与 3 7 1 % ,χ2 =4 63 ,P <0 0 5 )。结论 :补阳还五汤对原发性肾病综合征患者TXB2 、6 Keto PGF1α、ET、CGRP有改善作用 ,并通过这种作用 ,提高了疗效。 |
| 英文摘要: |
| Objective: To explore the mechanism of Buyang Huanwu Decoction (BHD) in treating primary nephrotic syndrome (PNS). Methods: Based on the treatment of prednisone acetate and cytoxan, two groups of PNS patients were treated with aspirin and persantin (western medicine group, 35 patients) and BHD and western medicine (TCM WM group, 35patients) respectively. The effect on anticoagulation was observed and compared. Plasma levels of thromboxane B 2 (TXB 2), 6 keto prostaglandin F 1α (6 Keto PGF 1α ), endothelin (ET), calcitonin gene related peptide (CGRP) were determined before and after treatment, and at the time of reducing dose and turning to maintenance dose of prednisone. The therapeutic effect of the two groups were also observed. Another group of 30 healthy person was established for control. Results: The difference of TXB 2, 6 Keto PGF 1α , ET, CGRP between patients and healthy persons was very significant before treatment(P<0 001). Above mentioned 4 parameters improved synchronously with the clinical improvement in the therapeutic course and they were better in the TCM WM group than those in the western medicine group (P<0 001) and the complete remission rate of the former group was also higher than that of the latter (62.9% vs 37.1%, χ 2=4.63, P<0 05). Conclusion: BHD could improve the therapeutic effect in treating PNS through the mechanism of improving TXB 2, 6 Keto PGF 1α , ET and CGRP levels. |
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