| 韩咏竹,何光远,王训,李凯,王共强,杨任民.中药肝豆片Ⅰ号与二巯基丁二酸治疗肝豆状核变性疗效的比较[J].,1999,(2):69-70 |
| 中药肝豆片Ⅰ号与二巯基丁二酸治疗肝豆状核变性疗效的比较 |
| Comparative Study on Therapeutic Effects of Gandou Tablet Ⅰ and Dimercaptosuccinate Acid in Treating Wilson Disease |
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| DOI： |
| 中文关键词: 肝豆片Ⅰ号 二巯基丁二酸 肝豆状核变性 |
| 英文关键词:Gandou Ⅰ dimercaptosuccinate acid hepatolenticular degeneration |
| 基金项目:国家自然科学基金,安徽省教委自然科学基金 |
| Author Name | Affiliation | | 韩咏竹 | Han Yongzhu, He Guangyuan, Wang Xun, et al Institute of Neurology, Anhui College of TCM, Hefei(230031 | | 何光远 | Han Yongzhu, He Guangyuan, Wang Xun, et al Institute of Neurology, Anhui College of TCM, Hefei(230031 | | 王训 | Han Yongzhu, He Guangyuan, Wang Xun, et al Institute of Neurology, Anhui College of TCM, Hefei(230031 | | 李凯 | Han Yongzhu, He Guangyuan, Wang Xun, et al Institute of Neurology, Anhui College of TCM, Hefei(230031 | | 王共强 | Han Yongzhu, He Guangyuan, Wang Xun, et al Institute of Neurology, Anhui College of TCM, Hefei(230031 | | 杨任民 | Han Yongzhu, He Guangyuan, Wang Xun, et al Institute of Neurology, Anhui College of TCM, Hefei(230031 |
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| 中文摘要: |
| 目的：观察比较中药肝豆片Ⅰ号与二巯基丁二酸胶囊（ＤＭＳＡ）治疗肝豆状核变性的疗效。方法：９４例患者随机分为两组，Ａ组３２例予肝豆片Ⅰ号治疗，Ｂ组６２例予ＤＭＳＡ治疗，两组均治疗４周。以改良Ｇｏｌｄｓｔｅｉｎ分级法作疗效判断。结果：Ａ组总有效率（７１９％）与Ｂ组（７７４％）相似（Ｐ＞００５）；但Ｂ组不良反应发生率高于Ａ组（Ｐ＜００１）。结论：肝豆片Ⅰ号低毒、高效，更适宜长期口服，用于治疗肝豆状核变性安全、有效。 |
| 英文摘要: |
| Objective: To compare the effects of Gandou Ⅰ (GD, a Chinese herbal preparation) and dimercaptosuccinate acid (DMSA) in treating Wilson disease (WD). Methods: Ninety four patients with WD were divided into 2 groups, 32 cases in the GD group and 62 in the DMSA group, they were treated with GD and DMSA respectively. The therapeutic course was 4 weeks for both groups. Modified Goldstein’s Degree was adopted to evaluate the clinical effect. Results: The total effective rate of the GD group was 71.9%, which was similar to that of the DMSA group (77.4%,P>0 05). But the adverse reaction occurred in the latter group was more than that in the former. Conclusion: GD is a low toxic and highly effective drug for long term treatment of WD. |
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