| 黄镜,孙燕,陆士新,苏涛,焦顺昌.芦笋有效成分熊果酸诱导HL-60细胞凋亡的实验研究[J].,1999,(5):296-298 |
| 芦笋有效成分熊果酸诱导HL-60细胞凋亡的实验研究 |
| Experimental Study on Apoptosis Induced by Ursolic Acid Isolated from Asparagus in HL 60 Cells |
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| DOI： |
| 中文关键词: 熊果酸 HL-60细胞 凋亡 |
| 英文关键词:ursolic acid HL 60 cells apoptosis |
| 基金项目:“八五”国家医学科技攻关项目 |
| Author Name | Affiliation | | 黄镜 | Huang Jing, Sun Yan, Lu Shixin, et al Cancer Hospital and Institute, Peking Union Medical University, Chinese Academy of Medical Sciences, Beijing (100021 | | 孙燕 | Huang Jing, Sun Yan, Lu Shixin, et al Cancer Hospital and Institute, Peking Union Medical University, Chinese Academy of Medical Sciences, Beijing (100021 | | 陆士新 | Huang Jing, Sun Yan, Lu Shixin, et al Cancer Hospital and Institute, Peking Union Medical University, Chinese Academy of Medical Sciences, Beijing (100021 | | 苏涛 | Huang Jing, Sun Yan, Lu Shixin, et al Cancer Hospital and Institute, Peking Union Medical University, Chinese Academy of Medical Sciences, Beijing (100021 | | 焦顺昌 | Huang Jing, Sun Yan, Lu Shixin, et al Cancer Hospital and Institute, Peking Union Medical University, Chinese Academy of Medical Sciences, Beijing (100021 |
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| 中文摘要: |
| 目的：探讨芦笋有效成分熊果酸对ＨＬ ６０细胞增殖、凋亡的影响。方法：用ＭＴＴ法、ＤＮＡ凝胶电泳、形态学方法等测定熊果酸对ＨＬ ６０细胞增殖、凋亡的影响。结果：熊果酸抑制ＨＬ ６０细胞增殖，对ＨＬ ６０细胞的半数生长的抑制剂量（ＩＣ５０）为８２６μｍｏｌ／Ｌ，并能诱导其发生凋亡。结论：熊果酸通过抑制ＨＬ ６０细胞增殖和诱导其凋亡发挥抗肿瘤作用。 |
| 英文摘要: |
| Objective: To study the inhibitory effect of ursolic acid isolated from Asparagus on the proliferation of HL 60 cells. Methods: Effects of ursolic acid on the growth and apoptosis were evaluated by MTT assay, DNA gel electrophoresis and morphology observation respectively. Results: The IC 50 value of ursolic acid for HL 60 cells was found to be 8.26 μmol/L and 10～50 μmol/L of ursolic acid could induce apoptosis of HL 60 cells exposed to ursolic acid for 1 day. Conclusion: Ursolic acid can markedly inhibit HL 60 cells as well as induction of cells apoptosis. |
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