| 凌昌全,李敏,谭金兴,卢军华.中药对糖皮质激素受体保护作用的实验研究[J].,1999,(5):302-303 |
| 中药对糖皮质激素受体保护作用的实验研究 |
| Experimental Study on Protective Effect of Chinese Herbal Medicine on Glucocorticoid Receptor |
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| DOI： |
| 中文关键词: 参附汤 生脉散 糖皮质激素受体 |
| 英文关键词:Shenfu Decoction Shengmai Powder glucocorticoid receptor |
| 基金项目:国家自然科学基金 |
| Author Name | Affiliation | | 凌昌全 | Ling Changquan, Li Min, Tan Jinxing, et al Changhai Hospital, The Second Military Medical University, Shanghai (200433 | | 李敏 | Ling Changquan, Li Min, Tan Jinxing, et al Changhai Hospital, The Second Military Medical University, Shanghai (200433 | | 谭金兴 | Ling Changquan, Li Min, Tan Jinxing, et al Changhai Hospital, The Second Military Medical University, Shanghai (200433 | | 卢军华 | Ling Changquan, Li Min, Tan Jinxing, et al Changhai Hospital, The Second Military Medical University, Shanghai (200433 |
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| 中文摘要: |
| 目的：深入探讨中药与糖皮质激素受体之间的关系。方法：分别以急性失血性休克大鼠模拟气随血失、亡阳虚脱证，以热损伤大鼠模拟气阴两亏证，并根据辨证施治原理，观察参附汤和生脉散对模型大鼠肝胞液中糖皮质激素受体（ＧｃＲ）的影响。结果：两种模型大鼠血浆糖皮质激素（ＧＣ）含量明显增高的同时肝胞液ＧｃＲ均显著下降，参附汤和生脉散对相应模型大鼠血浆ＧＣ无明显调节作用，但对其肝胞液ＧｃＲ均有明显的上调作用。结论：参附汤和生脉散能分别上调失血性休克和热损伤大鼠肝胞液ＧｃＲ水平。 |
| 英文摘要: |
| Objective: To probe the relationship of glucocorticoid receptor and some Chinese medicinal herbs. Methods: The models of Qi Yang exhaustion and Qi Yin exhaustion were made with hemorrhagic rats and heat stressed rats respectively. The effect of Shenfu Decoction (SFD) and Shengmai Powder (SMP) on plasma glucocorticoid (GC) and its receptor (GcR) in hepatic cytosol of the models were measured respectively. Results: The activity of GcR decreased in both models, while their blood level of GC increased markedly. SFD and SMP showed no regulating effect on blood GC, but displayed obvious up regulation on GcR level in both models. Conclusion: SFD and SMP could up regulate the activity of GcR in Qi Yang and Qi Yin exhaustion models. |
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