| 杨宇飞,朱尧武,吴煜,郭全,荆妮,项春燕,储大同.中医药治疗恶性肿瘤综合疗效标准探讨及初步运用[J].,1999,(6):340-343 |
| 中医药治疗恶性肿瘤综合疗效标准探讨及初步运用 |
| Discussion and Preliminary Application on Standard for Comprehensive Efficacy Assessment of Traditional Chinese Medicine in Treating Malignant Tumor |
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| DOI： |
| 中文关键词: 恶性肿瘤 中医药 疗效标准 |
| 英文关键词:malignant tumor traditional Chinese medicine standard for therapeutic effect assessment |
| 基金项目: |
| Author Name | Affiliation | | 杨宇飞 | Yang Yufei, Zhu Yaowu, Wu Yu, et al Xiyuan Hospital, China Academy of TCM, Beijing (100091 | | 朱尧武 | Yang Yufei, Zhu Yaowu, Wu Yu, et al Xiyuan Hospital, China Academy of TCM, Beijing (100091 | | 吴煜 | Yang Yufei, Zhu Yaowu, Wu Yu, et al Xiyuan Hospital, China Academy of TCM, Beijing (100091 | | 郭全 | Yang Yufei, Zhu Yaowu, Wu Yu, et al Xiyuan Hospital, China Academy of TCM, Beijing (100091 | | 荆妮 | Yang Yufei, Zhu Yaowu, Wu Yu, et al Xiyuan Hospital, China Academy of TCM, Beijing (100091 | | 项春燕 | Yang Yufei, Zhu Yaowu, Wu Yu, et al Xiyuan Hospital, China Academy of TCM, Beijing (100091 | | 储大同 | Yang Yufei, Zhu Yaowu, Wu Yu, et al Xiyuan Hospital, China Academy of TCM, Beijing (100091 |
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| 中文摘要: |
| 目的：以恶性肿瘤患者生存期为前提，分别考察肿瘤及宿主对中医药治疗的反应，制定临床综合疗效判定标准。方法：以肿瘤大小变化、与肿瘤相关的主症变化、Ｋａｒｎｏｆｓｋｙ评分、体重等作为近期综合疗效判定指标，制定临床综合疗效判定标准，对１９９７年３月～１９９８年８月西苑医院肿瘤科接受不同治疗方案的晚期恶性肿瘤患者进行疗效评价，并与肿瘤客观缓解率（ＲＲ）进行比较分析。结果：５５例晚期恶性肿瘤患者，综合疗效评定，有效３０９１％（１７例），稳定１８１８％（１０例），恶化５０９１％（２８例）；而肿瘤客观缓解率的结果为ＣＲ为０，ＰＲ５４５％（３例），ＮＣ７４５５％（４１例），ＰＤ２０００％（１１例）。两种疗效标准比较，差异显著（Ｐ＜０００５）。本组病例中１８例晚期肺癌中位生存期１１５个月，大于中位生存期的患者中，大部分是带瘤生存，在肿瘤客观缓解率的ＮＣ中，却在综合疗效标准的有效档内。结论：综合疗效标准较客观缓解率强调生存质量，同时反映了肿瘤与宿主对治疗的反应，较好地反映了肿瘤的预后，与生存期有一定相关，通过实践进一步完善，可以作为晚期恶性肿瘤的临床疗效评定标准。 |
| 英文摘要: |
| Objective: To establish a comprehensive efficacy assessment standard on premise of patients′ survival period and referring to the response of tumor and host to traditional Chinese medicine (TCM) therapy. Methods: A standard was established by taking change of tumor size, tumor related symptoms, Karnofsky scoring and body weight of patient as criteria for evaluation. The standard was used to evaluate the comprehensive effect on advanced tumor patients, received various therapeutic regimen of TCM treatment in Xiyuan Hospital from March 1997 to August 1998, and compared with that evaluated by objective response rate (RR) of tumor. Results: By the new standard, comprehensive therapeutic effect of 55 advanced tumor patients was: effective in 17 cases (30.91%), stable in 10 (18.18%) and exacerbative in 28 (50.91%),while by RR, it was completely response in 0, partial response in 3 (5.45%), no change in 41 (74.55%) and progre ssive disease in 11 (20.00%) . Results of evaluation made by the two standard was different significantly, P<0 005. The median survival period of 18 cases of advanced lung carcinoma patients was 11.5 months. Patients survived longer than the median survival period, mostly were tumor bearing survival, were attributed to no change by RR, but were listed as effective by the new standard. Conclusion: The new standard laid more stress on quality of life than the RR, it reflects better response of tumor and host to treatment, and the prognosis of patients, and associated with the survival period, therefore, it could be conducted as the standard for comprehensive efficacy assessment in treating advanced malignant tumor in clinical practice after further improving. |
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