| 花宝金,王爱平,侯炜.复方仙酥胶囊联合化疗治疗中晚期胃癌的临床研究[J].,1999,(8):470-472 |
| 复方仙酥胶囊联合化疗治疗中晚期胃癌的临床研究 |
| Clinical Study on Treatment of Mid Late Stage Gastric Carcinoma by Composite Xiansu Capsule Combined with Chemotherapy |
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| DOI： |
| 中文关键词: 复方仙酥胶囊 化疗 T淋巴细胞亚群 胃癌 |
| 英文关键词:composite Xiansu Capsule chemotherapy T lymphocyte subset gastric carcinoma |
| 基金项目:国家中医药管理局科研基金 |
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| 中文摘要: |
| 目的：探讨复方仙酥胶囊配合化疗治疗中晚期胃癌的疗效及机理。方法：以复方仙酥胶囊配合化疗治疗６１例中晚期胃癌患者，并与单纯化疗３０例作对照，观察两组有效率、细胞免疫功能等。结果：对带瘤患者治疗组有效率为３２８％，对照组为１３３％（Ｐ＜００５），而毒副反应发生率治疗组低于对照组（Ｐ＜００１）。治疗组患者ＣＤ８下降，ＣＤ４／ＣＤ８升高，说明复方仙酥胶囊对Ｔ细胞免疫功能有调节作用。结论：复方仙酥胶囊对化疗有增效减毒作用，其调节细胞免疫功能可能是取得疗效机理之一。 |
| 英文摘要: |
| Objective: To assess the effect and mechanism of composite Xiansu Capsule (CXSC) combined with chemotherapy in treating gastric carcinoma of mid late stage. Methods: The 61 patients of the test group were treated by CXSC combined with chemotherapy and 30 patients of the control group treated with chemotherapy alone. The effect of treatment and cell mediated immunity of patients were observed. Results: The effective rate of the test group and the control group was 32.8% and 13.3% respectively (P<0 05), the chemotherapy caused toxic reaction occurrence was less in the former than that in the latter group (P<0 01). The CD 3 level of patients in the test group was decreased, and CD 4/CD 8 level was raised obviously, which suggested that CXSC had immuno regulating effect on T cells. Conclusion: CXSC could enhance the efficacy and reduce the toxic side effect of chemotherapy. To regulate the cell mediated immunity of patients is possibly its mechanism. |
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