| 胡晓梅,马玲,胡乃平,王忠芬,杨留,李柳,王展翔,王洪志,王楠,刘驰,刘锋,杨经敏,麻柔.癌灵一号治疗急性早幼粒细胞白血病62例[J].,1999,(8):473-476 |
| 癌灵一号治疗急性早幼粒细胞白血病62例 |
| Ailing No. I in Treating 62 Cases of Acute Promyelocytic Leukemia |
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| DOI： |
| 中文关键词: 癌灵一号 白血病 髓细胞性 急性治疗 |
| 英文关键词:Ailing No. I acute promyelocytic leukemia myelocytic acute treatment |
| 基金项目: |
| Author Name | Affiliation | | 胡晓梅 | Hu Xiaomei, Ma Ling, Hu Naiping, et al Xiyuan Hospital, China Academy of TCM, Beijing (100091 | | 马玲 | Hu Xiaomei, Ma Ling, Hu Naiping, et al Xiyuan Hospital, China Academy of TCM, Beijing (100091 | | 胡乃平 | Hu Xiaomei, Ma Ling, Hu Naiping, et al Xiyuan Hospital, China Academy of TCM, Beijing (100091 | | 王忠芬 | Hu Xiaomei, Ma Ling, Hu Naiping, et al Xiyuan Hospital, China Academy of TCM, Beijing (100091 | | 杨留 | Hu Xiaomei, Ma Ling, Hu Naiping, et al Xiyuan Hospital, China Academy of TCM, Beijing (100091 | | 李柳 | Hu Xiaomei, Ma Ling, Hu Naiping, et al Xiyuan Hospital, China Academy of TCM, Beijing (100091 | | 王展翔 | Hu Xiaomei, Ma Ling, Hu Naiping, et al Xiyuan Hospital, China Academy of TCM, Beijing (100091 | | 王洪志 | Hu Xiaomei, Ma Ling, Hu Naiping, et al Xiyuan Hospital, China Academy of TCM, Beijing (100091 | | 王楠 | Hu Xiaomei, Ma Ling, Hu Naiping, et al Xiyuan Hospital, China Academy of TCM, Beijing (100091 | | 刘驰 | Hu Xiaomei, Ma Ling, Hu Naiping, et al Xiyuan Hospital, China Academy of TCM, Beijing (100091 | | 刘锋 | Hu Xiaomei, Ma Ling, Hu Naiping, et al Xiyuan Hospital, China Academy of TCM, Beijing (100091 | | 杨经敏 | Hu Xiaomei, Ma Ling, Hu Naiping, et al Xiyuan Hospital, China Academy of TCM, Beijing (100091 | | 麻柔 | Hu Xiaomei, Ma Ling, Hu Naiping, et al Xiyuan Hospital, China Academy of TCM, Beijing (100091 |
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| 中文摘要: |
| 目的：进一步了解癌灵一号治疗急性早幼粒细胞白血病（ＡＰＬ）的疗效、作用机制及毒副反应。方法：运用癌灵一号作诱导及巩固治疗６２例ＡＰＬ，观察其完全缓解（ＣＲ）率，治疗前后临床症状、外周血象、骨髓象、脏器功能及免疫指标等的变化。结果：诱导缓解治疗３１例，取得ＣＲ２７例，ＣＲ率为８７１％；巩固治疗３１例，持续缓解时间最长为３７个月，有７例在１个月～２年内复发。诱导治疗１周后ＷＢＣ显著升高，４周后明显下降；巩固治疗１周后ＷＢＣ开始下降，４周后呈回升趋势。Ｈｂ变化不大。Ｐｌｔ治疗后较治疗前显著升高。对骨髓（ＢＭ）抑制不明显。治疗前后Ｔ细胞亚群及免疫球蛋白测定值无明显变化。临床毒副反应表现多端，以消化道反应为突出，对肝脏有一定的损害。结论：癌灵一号疗效好，缓解率高，疗效持久，其作用可能与诱导分化及细胞毒作用双重机制有关 |
| 英文摘要: |
| Objective: To obtain further knowledge on the effect, mechanism and toxic side effect of Ailing No. I (AL), a preparation of As 2O 3, in treating acute promyelocytic leukemia (APL). Methods: AL was used in induction and consolidation treatment of 62 cases of APL, the effect of treatment and the changes of clinical symptoms, peripheral blood and bone marrow pictures, T lymphocyte subset, and immunofunctions of patients after treatment were observed. Results: Twenty seven cases out of the 31 patients who received induction treatment got complete remission (CR), the CR rate being 87.1%. Of the 31 cases who received consolidation treatment, the longest remission period was 37 months, and 7 cases relapsed within one month to 2 years. Peripheral white blood cell count raised after one week but lowered after 4 weeks of induction treatment, but in receiving consolidation treatment, it started to lower after one week and raised after 4 weeks of treatment. No obvious change on hemoglobin level was observed. Platelet count significantly increased after treatment. The treatment showed no obvious inhibiton on bone marrow. The T lymphocyte subsets and immunoglobulin level were changed insignificantly after treatment. Various side effects were shown clinically, particularly those digestive tract involved symptoms were prominent, and liver damage was shown in a certain degree. Conclusion: AL has good and protracted effect in treating APL with high CR rate, the mechanism may be related with its cytotoxicity and action of differentiation induction. |
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