| 王少媛,辛凯旋,马端,杜向阳,王言森.川芎嗪对肺心病急性加重期患者血浆血小板聚集率、血栓素B2、6-酮-前列腺素F1α、血管性假血友病因子及血气的影响[J].,1999,(10):602-604 |
| 川芎嗪对肺心病急性加重期患者血浆血小板聚集率、血栓素B2、6-酮-前列腺素F1α、血管性假血友病因子及血气的影响 |
| Effects of Ligustrazine on Plasma Platelet Aggregation Rate, Thyromboxane B2,6-keto-Prostaglandin F1α and Von Willebrand′s Factor in Patients with Acute Onset of Cor Pulmonale |
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| DOI： |
| 中文关键词: 川芎嗪 肺心病 血小板功能 内皮细胞功能 |
| 英文关键词:Ligustrazine cor pulmonale platelet function function of endothelial cells |
| 基金项目: |
| Author Name | Affiliation | | 王少媛 | Wang Shaoyuan, Xin Kaixuan, Ma Duan, et al Shandong Traffic Hospital, Jinan (250031 | | 辛凯旋 | Wang Shaoyuan, Xin Kaixuan, Ma Duan, et al Shandong Traffic Hospital, Jinan (250031 | | 马端 | Wang Shaoyuan, Xin Kaixuan, Ma Duan, et al Shandong Traffic Hospital, Jinan (250031 | | 杜向阳 | Wang Shaoyuan, Xin Kaixuan, Ma Duan, et al Shandong Traffic Hospital, Jinan (250031 | | 王言森 | Wang Shaoyuan, Xin Kaixuan, Ma Duan, et al Shandong Traffic Hospital, Jinan (250031 |
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| 中文摘要: |
| 目的 :研究大剂量川芎嗪对肺心病急性加重期患者血小板功能和血管内皮细胞功能及血气的影响。方法 :将 5 6例肺心病急性加重期患者分为川芎嗪治疗组 ( 30例 )和对照组 ( 2 6例 ) ,分别于治疗前后采用比浊法、酶标法等测定血小板聚集率 (PAR)、血栓素B2 (TXB2 )、6 酮 前列腺素F1α( 6 keto PGF1α)、血管性假血友病因子 (vWF)、动脉血氧分压 (PaO2 )和二氧化碳分压 (PaCO2 )、氧饱和度 (SaO2 )水平。结果 :川芎嗪治疗组PAR、vWF、TXB2 、TXB2 / 6 keto PGF1α和PaCO2 明显下降 (P <0 0 5 ,P <0 0 1) ,6 keto PGF1α,PaO2 和SaO2 明显上升 (P <0 0 1,P <0 0 5 ) ,对照组仅PaCO2 下降 (P <0 0 5 )。结论 :大剂量川芎嗪具有抗血小板、保护血管内皮细胞的作用 ,使PaO2 、SaO2 升高 ,PaCO2 下降 ,且每日使用 80 0mg安全无副作用。 |
| 英文摘要: |
| Objective: To study the effect on large dose of Ligustrazine on the function of platelet and endothelial cells of patients with acute onset of cor pulmonale. Methods: Platelet aggregation rate (PAR), thromboxane B 2(TXB 2), 6 keto prostaglandin F 1α (6 keto PGF 1α ), von Willebrand′s factor (vWF), PaO 2 and PaCO 2 were assayed in 30 patients with acute onset of cor pulmonale and 26 cases of control before and after treatment of large dose of Ligustrazine. Results: PAR, vWF, TXB 2, TXB 2/6 keto PGF 1α and PaCO 2 decreased (P<0 05, P<0 01), and 6 keto PGF 1α , PaO 2, SaO 2 increased (P<0 01) after treatment of Ligustrazine, and only PaCO 2 decreased in control. Conclusion: Ligustrazine had the function of antiplatelet and protecting the endothelial cells. Large dose (800mg/d) had no side effects. |
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