| 郭立中,刘玉宁,毛炜,叶传蕙,顾云,周姗姗.肾康注射液与苯那普利对肾小球系膜基质作用的对比研究[J].,2000,(1):50-52 |
| 肾康注射液与苯那普利对肾小球系膜基质作用的对比研究 |
| Contrast Study on Effect of Shenkang Injection and Benazepril on Human Glomerular Mesangial Extracellular Matrix |
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| DOI： |
| 中文关键词: 肾康注射液 苯那普利 系膜细胞 细胞外基质 |
| 英文关键词:Shenkang Injection Benazepril mesangial cell extracellular matrix |
| 基金项目:国家中医药管理局资助! (No.92DO89) |
| Author Name | Affiliation | | 郭立中 | GUO Lizhong, LIU Yuning, MAO Wei, et al Nanjing University of TCM, Nanjing (210029 | | 刘玉宁 | GUO Lizhong, LIU Yuning, MAO Wei, et al Nanjing University of TCM, Nanjing (210029 | | 毛炜 | GUO Lizhong, LIU Yuning, MAO Wei, et al Nanjing University of TCM, Nanjing (210029 | | 叶传蕙 | GUO Lizhong, LIU Yuning, MAO Wei, et al Nanjing University of TCM, Nanjing (210029 | | 顾云 | GUO Lizhong, LIU Yuning, MAO Wei, et al Nanjing University of TCM, Nanjing (210029 | | 周姗姗 | GUO Lizhong, LIU Yuning, MAO Wei, et al Nanjing University of TCM, Nanjing (210029 |
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| 中文摘要: |
| 目的 :探讨肾康注射液与苯那普利对人肾小球系膜细胞外基质 (ECM )不同成分的抑制作用强度。方法 :采用体外培养的人肾小球系膜细胞技术 ,观察具有降逆泄浊、益气活血功效的中药肾康注射液及苯那普利对ECM不同成分的影响。结果 :肾康注射液具有抑制ECM成分中纤维连接蛋白 (FN)、层粘连蛋白 (LN)和Ⅳ型胶原 (ColⅣ )的作用 ,该抑制作用具有一定的量效关系。苯那普利对ECM中FN、ColⅣ也有一定的抑制作用 ,但不及肾康注射液作用明显。结论 :肾康注射液对ECM的抑制作用优于苯那普利。 |
| 英文摘要: |
| Objective: To explore the intensity of inhibition of Shenkang Injection (SKI) and Benazepril on various ingredients of human glomerular mesangial extracellular matrix (ECM). Methods: Effect of SKI, a herbal preparation for lowering adverse Qi, despelling turbidness, supplementing Qi and activating circulation, and Benazepril were observed by cultured glomerular mesangial cell technique in vitro. Results: SKI could inhibit the fibronetin, laminin, and type Ⅳ collagen of ECM, and the action was dose dependent. Benazepril could also inhibit the fibronetin and type Ⅳ collagen of ECM but was weaker in intensity. Conclusion: The effect of SKI was superior to Benazepril in inhibiting ECM. |
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