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目的:对多发梗塞性痴呆大鼠模型进行方法学改进,以此模型对健脑益智冲剂进行药效学观察。方法:从颈外动脉逆行插管注入血栓栓子造模,观察行为学和病理形态学的影响。结果:造模后脑内存在广泛而多发的梗塞灶,学习记忆能力明显下降(P<001,P<005),中药健脑益智冲剂和喜得镇(Hydergine)药物干预后,上述改变得以明显改善。结论:此模型是进行多发梗塞性痴呆基础研究和筛选新药的理想模型。

英文摘要:

To improve the method of inducing the multi infarct dementia (MID) model in rats to observe the pharmacodynamic effect of Jiannao Yizhi (JNYZ) granule on MID. Methods: Retrograde injection with the homologous embolus through the external carotid artery initiated the multi infarct dementia in rats. The experiment of behavior and morphology were conducted. Results: The extensive and multiple foci of infarction and the obviously declining ability of learning and memory were observed in the model group; the action of JNYZ granule and hydergine could obviously improve them. Conclusion: This model is useful to carry out basic research and screen new drugs in treating MID.

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