| 王琳,王天芳,康纯洁,刘晓兰,刘燕,张翠珍,郑君芳.消疲怡神口服液对应激大鼠下丘脑—垂体—肾上腺—胸腺轴影响的实验研究[J].,2000,(2):116-119 |
| 消疲怡神口服液对应激大鼠下丘脑—垂体—肾上腺—胸腺轴影响的实验研究 |
| Effects of Xiaopi Yishen Oral Liquid on Hypothalamus Pituitary Adrenal Gland Thymus Axis in Stressed Rats |
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| DOI： |
| 中文关键词: 消疲怡神口服液 强制冷水游泳 下丘脑—垂体—肾上腺—胸腺轴 |
| 英文关键词:Xiaopi Yishen oral liquid repeated forced cold water swimming hypothalamus pituitary adrenal gland thymus axis |
| 基金项目:国家自然科学基金!No .3950 0 1 84;国家中医药管理局!No.95B1 0 9 |
| Author Name | Affiliation | | 王琳 | WANG Lin, WANG Tianfang, KANG Chunjie, et al Beijing University of Traditional Chinese Medicine, Beijing (100029 | | 王天芳 | WANG Lin, WANG Tianfang, KANG Chunjie, et al Beijing University of Traditional Chinese Medicine, Beijing (100029 | | 康纯洁 | WANG Lin, WANG Tianfang, KANG Chunjie, et al Beijing University of Traditional Chinese Medicine, Beijing (100029 | | 刘晓兰 | WANG Lin, WANG Tianfang, KANG Chunjie, et al Beijing University of Traditional Chinese Medicine, Beijing (100029 | | 刘燕 | WANG Lin, WANG Tianfang, KANG Chunjie, et al Beijing University of Traditional Chinese Medicine, Beijing (100029 | | 张翠珍 | WANG Lin, WANG Tianfang, KANG Chunjie, et al Beijing University of Traditional Chinese Medicine, Beijing (100029 | | 郑君芳 | WANG Lin, WANG Tianfang, KANG Chunjie, et al Beijing University of Traditional Chinese Medicine, Beijing (100029 |
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| 中文摘要: |
| 目的:探讨消疲怡神口服液抗应激的作用机理。方法:观察了消疲怡神口服液对强制冷水游泳大鼠模型血清单胺类物质、肾上腺抗坏血酸和下丘脑垂体单胺类递质含量及胸腺指数的影响。结果:消疲怡神口服液可以拮抗应激所致血清多巴胺、5羟色胺含量升高和肾上腺抗坏血酸含量降低,使降低的下丘脑垂体去甲肾上腺素、5羟色胺含量回升,但对胸腺指数无明显影响。结论:消疲怡神口服液的作用机制与其对机体下丘脑—垂体—肾上腺—胸腺轴的调节有关。 |
| 英文摘要: |
| To investigate the effect of Xiaopi Yishen (XPYS) oral liquid on the rats under repeated forced cold water swimming (RFCWS) stress. Methods: The changes of serum monoamine, ascorbic acid levels in adrenal gland, monoamine levels in hypothalamus and hypophysis, and thymus index were determined. Results: XPYS lowered the increasing of serum DA, 5 HT, improved the reducing of ascorbic acid in adrenal gland and NE, HVA, 5 HT, 5 HITT in hypothalamus and hypophysis of RFCWS stressed rats. Conclusion: The mechanism of XPYS is in connection with the regulation of hypothalamus pituitary adrenal gland thymus axis. |
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