| 唐蜀华,蒋卫民,陈晓虎,严冬.针箭颗粒改善高血压病胰岛素抵抗的临床研究[J].,2000,(7):511-514 |
| 针箭颗粒改善高血压病胰岛素抵抗的临床研究 |
| Clinical Study on Zhenjian Granule in Improving Essential Hypertension and Insulin Resistance |
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| DOI： |
| 中文关键词: 高血压病 胰岛素抵抗 针箭颗粒 |
| 英文关键词:essential hypertension insulin resistance Zhenjian granule |
| 基金项目:江苏省科委资助课题!（No．BS98067） |
| Author Name | Affiliation | | 唐蜀华 | TANG Shuhua, JIANG Weimin, CHEN Xiaohu, et al (Cardiovascular Department, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing (210029) | | 蒋卫民 | TANG Shuhua, JIANG Weimin, CHEN Xiaohu, et al (Cardiovascular Department, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing (210029) | | 陈晓虎 | TANG Shuhua, JIANG Weimin, CHEN Xiaohu, et al (Cardiovascular Department, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing (210029) | | 严冬 | TANG Shuhua, JIANG Weimin, CHEN Xiaohu, et al (Cardiovascular Department, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing (210029) |
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| 中文摘要: |
| 目的：观察针箭颗粒的降压及改善高血压病（ＥＨ）胰岛素抵抗（ＩＲ）的作用。方法：将５２例ＥＨ患者随机分为治疗组３０例和对照组２２例，分别给予针箭颗粒和卡托普利治疗４周，观察治疗前后血压、空腹及餐后２ｈ血糖、胰岛素（放免法）、胰岛素敏感指数（ＩＳＩ）和血脂的变化，并与健康对照组１７名比较。结果：治疗前两组患者空腹胰岛素及餐后２ｈ血糖、胰岛素含量明显高于健康对照组（Ｐ＜ ０．０１），ＩＳＩ明显低于健康对照组（Ｐ＜０．０１），说明存在ＩＲ；治疗后不仅血压明显下降（Ｐ＜０．０５，Ｐ＜０．０１），而且空腹胰岛素，餐后２ｈ血糖、胰岛素均显著降低（Ｐ＜０．０５，Ｐ＜０．０１），ＩＳＩ显著升高（Ｐ＜ ０．０５，Ｐ＜０．０１），两组ＩＲ均得到改善，治疗组血脂也有明显改善。结论：针箭颗粒不仅具有确切的降压效应，而且对ＥＨ所伴有的代谢障碍特别是ＩＲ具有明确的改善作用。 |
| 英文摘要: |
| To observe the effect of Zhenjian granule (ZJG) on lowering the blood pressure and improving the essential hypertension (EH) and insulin resistance (IR). Methods: Fifty-two hypertensive patients were randomly divided into the treated group (30 patients) with ZJG and the control group (22 patients) with captopril for 4 weeks, then the variation of levels of blood pressure, blood glucose, blood insulin (radioimmunoassay), insulin sensitivity index (ISI) and blood lipid before and after treatment were determined, and compared with the normal group (17 healthy subjects). Results: Fasting insulin, blood glucose and insulin 2 hours after meal were significantly higher than those of the normal control, but the ISI was significantly lower than that of the normal control (P < 0. 01), the insulin resistance existed; after treatment, not only the blood pressure obviously lowered (P < 0. 05, P < 0. 01), and the fasting insulin, blood glucose and insulin 2 hours after meal obviously lowered (P< 0. 05, P< 0. 01), ISI markedly raised (P< 0. 05, P< 0. 01),. The IR of both groups was improved, the blood lipid of the treated group was also improved. Conclusion: ZJG was effective in reducing blood pressure, it also had significant effect on improving metabolic disorder, particularly on IR in EH patients. |
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