| 韩谷鸣,姚倩,李洪莲,王永平.穿心莲黄酮对血小板活化反应的抑制作用及机理研究[J].,2000,(7):527-529 |
| 穿心莲黄酮对血小板活化反应的抑制作用及机理研究 |
| nhibitory Effect of Panicoin on Platelet Activation and Its Mechanism |
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| DOI： |
| 中文关键词: 穿心莲黄酮 血小板活化 花生四烯酸 cAMP |
| 英文关键词:Panicoin platelet activation arachidonic acid cyclic AMP |
| 基金项目:江苏省科委资助项目!（BJ91065） |
| Author Name | Affiliation | | 韩谷鸣 | HAN Guming, YAO Qian, LI Honglian, et al (Xuzhou Geriatrics Institute, Jiangsu (221003) | | 姚倩 | HAN Guming, YAO Qian, LI Honglian, et al (Xuzhou Geriatrics Institute, Jiangsu (221003) | | 李洪莲 | HAN Guming, YAO Qian, LI Honglian, et al (Xuzhou Geriatrics Institute, Jiangsu (221003) | | 王永平 | HAN Guming, YAO Qian, LI Honglian, et al (Xuzhou Geriatrics Institute, Jiangsu (221003) |
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| 中文摘要: |
| 目的：探讨穿心莲黄酮抑制血小板活化反应的途径和可能机理。方法：观察穿心莲黄酮对二磷酸腺苷（ＡＤ Ｐ）、肾上腺素、花生四烯酸（ＡＡ）、凝血酶诱导的血小板聚集、血栓素Ｂ２（ＴＸＢ２）释放、Ｐ－选择素（ＧＭＰ－１４０）及血小板内环磷酸腺苷（ｃＡＭＰ）、环磷酸鸟苷（ｃＧＭＰ）水平的影响。结果：（１）穿心莲黄酮可明显抑制ＡＤＰ、ＡＡ、肾上腺素诱导的血小板聚集，并呈明显的正相关；（２）穿心莲黄酮可明显降低凝血酶诱导的ＧＭＰ－１４０水平；（３）穿心莲黄酮可明显抑制ＡＡ诱导的血小板ＴＸＢ２的释放，并可明显升高血小板内ｃＡＭＰ的含量，对ｃＧＭＰ含量无明显影响。结论：穿心莲黄酮具有较强的抑制血小板活化反应和抗血栓形成的作用，升高血小板内的ｃＡＭＰ水平可能为其作用机理之一。 |
| 英文摘要: |
| To explore the inhibitory pathway and the possible mechanism of panicoin on platelet activation. Methods: The effect of panicoin on platelet aggregation, thromboxane B2 release, P-selectin (GMP-140) count, levels of cyclic AMP and cyclic GMP induced by ADP, epinephrine, arachidonic acid (AA) or thrombin were observed. Results: (1) Panicoin significantly inhibits platelet aggregation induced by ADP, arachidonic acid and epinephrine in a dose-dependent manner; (2) It reduces the P-selectin number on platelet surface which was stimulated by thrombin; (3) It inhibits TXB2 release induced by AA and increases the platelet cyclic AMP level, while cyclic GMP level was not changed. Conclusion: Panicoin shows a potent inhibition on platelet activation and antithrombotic effect. The mechanisms seem to be related with the elevation of platelet cyclic AMP. |
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